Dihydroxydimethoxychalcone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dihydroxydimethoxychalcone?

Dihydroxydimethoxychalcone belongs to the chalcone family, a group of naturally occurring compounds often found in plants like licorice and hops. While small amounts can be extracted from botanical sources, the ingredient used in cosmetics is usually created in a lab for purity and consistency. Chemists make it by linking two aromatic rings through a simple reaction called Claisen-Schmidt condensation, which joins a substituted benzaldehyde with a matching acetophenone. This controlled process yields a fine, pale powder that dissolves well in water-glycerin mixes and many alcohol-based solutions.

Interest in chalcones grew during the 1990s when researchers noticed their ability to bind water and calm skin irritation. Formulators soon tested synthetic versions in moisturizers and found they improved skin feel without leaving a greasy film. Today you will spot Dihydroxydimethoxychalcone in lightweight serums, sheet masks, soothing after-sun gels, anti-aging creams and leave-on night treatments where steady hydration and a soft finish are important.

Dihydroxydimethoxychalcone’s Cosmetic Benefits/Uses

This ingredient supports skin comfort and moisture balance in several ways:

  • Humectant – attracts water from the environment and the deeper skin layers to the surface, helping to keep skin plump, flexible and less prone to fine lines
  • Skin conditioning – leaves a smooth, silky touch on application which can reduce rough texture and boost the overall sensory feel of a formula

Who Can Use Dihydroxydimethoxychalcone

This humectant is generally well tolerated by all skin types, including oily, combination, normal, dry and sensitive skin, because it hydrates without clogging pores or leaving a heavy residue. Those with very reactive or highly sensitized skin may wish to introduce it gradually since any new ingredient can be a wild card for an already compromised barrier.

The compound is synthesized in a lab and contains no animal-derived substances, making it suitable for vegans and vegetarians. Most manufacturers also avoid animal testing for this raw material, though cruelty-free status should be verified with the finished brand.

Current research has not flagged any specific risks for pregnant or breastfeeding women when the ingredient is used topically in cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should consult a healthcare professional before adding new skincare products, just to be safe.

Dihydroxydimethoxychalcone does not increase photosensitivity and can be used day or night without raising the risk of sunburn. Standard sun protection is still recommended whenever skin is exposed to daylight.

Potential Side Effects/Adverse Reactions

Responses to topical Dihydroxydimethoxychalcone vary from person to person. The issues listed below are possible yet uncommon when the ingredient is properly formulated and used as directed.

  • Mild redness or warmth
  • Temporary stinging on very compromised skin
  • Rare allergic contact dermatitis in individuals sensitive to chalcone derivatives
  • Eye irritation if the product migrates into the eye area

If any of these reactions occur discontinue use and seek guidance from a medical professional.

Comedogenic Rating

Rating: 0 / 5

Dihydroxydimethoxychalcone is a small, water soluble molecule with no oily chains or waxy residues that could block pores. It sits lightly on the skin, pulls in water then evaporates or rinses away without leaving a film, so it does not encourage the buildup of dead cells or sebum that can trigger blackheads and pimples. As a result it is considered safe for people who are prone to acne and breakouts.

Because the ingredient is usually used at low percentages and paired with non occlusive carriers, its comedogenic risk stays minimal even in richer formulas.

Summary

Dihydroxydimethoxychalcone acts mainly as a humectant and skin conditioning agent. The two hydroxyl groups latch onto water molecules and draw them toward the upper layers of the skin, improving hydration and plumping fine lines. At the same time the dimethoxy portions give a faint slip that softens rough texture so products feel silky rather than sticky.

It is still a niche ingredient, appearing far less often than all-stars like glycerin or hyaluronic acid, yet formulators who want a light touch and quick absorbing finish have started adding it to modern serums and masks.

Current data shows it is low risk for irritation or clogged pores, making it a safe choice for most users. That said, skin can be unpredictable so it is wise to patch test any new product containing this or any other active.

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