What Is Dihydroxypropyl Didehydrolatanoprostamide?
Dihydroxypropyl Didehydrolatanoprostamide is a lab designed lipid molecule, related to prostaglandin analogues that were first explored for their ability to influence hair follicles. Chemists modified the parent structure to create a version that works well on the surface of skin and scalp without the drug like activity of earlier compounds. The ingredient is sometimes listed by its alternative description, Dihydroxypropyl Dehydrodeethylbimatoprost, reflecting small tweaks in the tail of the molecule that improve stability in cosmetic bases.
Production begins with plant derived glycerol that supplies the dihydroxypropyl group. This is bonded to a carefully synthesized fatty acid chain through a series of controlled reactions in stainless steel reactors. Purification steps use filtration and low temperature crystallization to remove by-products, yielding a clear oil that blends easily into water in oil emulsions.
The ingredient entered cosmetic labs in the late 2010s when formulators looked for new ways to support fuller looking lashes and brows. Today you can find it in lash and brow serums, scalp leave-ins, thickening conditioners, overnight hair masks and some multi benefit facial serums targeting sparse hairlines.
Dihydroxypropyl Didehydrolatanoprostamide’s Cosmetic Benefits/Uses
This ingredient is added to products primarily for its effect on the look and feel of hair.
As a hair conditioning agent it helps soften the hair shaft, improve slip and reduce breakage during brushing. By coating individual strands it gives lashes, brows and scalp hair a smoother surface that reflects light better so hair appears healthier and slightly fuller. The conditioning film also helps lock in moisture which can support flexibility and minimize brittleness over time.
Who Can Use Dihydroxypropyl Didehydrolatanoprostamide
This conditioning lipid is generally well tolerated by all skin and scalp types, including dry, oily and combination. People with highly sensitive or reactive skin can still try it but should watch for any tingling or redness because the molecule is related to bioactive prostaglandin analogues that may trigger mild irritation in a small number of users.
Dihydroxypropyl Didehydrolatanoprostamide is synthesized from plant derived glycerol and other non animal inputs so it is suitable for vegans and vegetarians. Brands using it most often state they do not test this ingredient on animals.
There is limited published research on topical use during pregnancy or breastfeeding. While no specific problems have been reported, the lack of robust safety data means pregnant or nursing individuals should ask their doctor before adding products containing this ingredient. This information is educational only and not a substitute for medical advice.
The molecule is not known to increase photosensitivity and does not interact with sunlight in a way that would boost the risk of sunburn. It can be used year round without special sun care steps beyond standard daily SPF.
Dihydroxypropyl Didehydrolatanoprostamide works well alongside most common hair and skin actives and does not interfere with color treated hair. Store products in a cool, dry place to maintain stability.
Potential Side Effects/Adverse Reactions
- Mild skin irritation slight redness or stinging at the application site, more noticeable on very sensitive skin
- Itching or dryness temporary flakiness or itchiness on the scalp or lash line
- Periorbital darkening gradual darkening of skin around the eyes if used in lash serums and the product remains on the same spot over time
- Eye irritation watering or burning sensation if serum accidentally enters the eye
- Allergic contact dermatitis rare allergic rash or swelling for individuals with specific sensitivities to the molecule
- Unwanted hair growth fine hairs appearing on areas of skin that repeatedly come into contact with the product
If any of these effects occur stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 1 out of 5. Dihydroxypropyl Didehydrolatanoprostamide is an ester-like lipid that forms an ultra thin film on hair shafts rather than sitting heavily inside pores. Its molecular size is larger than typical pore-clogging fatty acids and it is usually used at low concentrations in leave-on lash or brow formulas, so the chance of blocking follicles is very low.
Suitable for acne-prone or breakout-prone skin in most cases.
Products that pair the ingredient with heavy waxes or butters could raise the overall comedogenicity of the final formula, so check the full ingredient list if congestion is a concern.
Summary
Dihydroxypropyl Didehydrolatanoprostamide is a lab crafted conditioning lipid that smooths hair cuticles, improves slip and helps lashes brows and scalp strands look fuller by reflecting more light. It accomplishes these benefits by forming a lightweight flexible film that locks in moisture without weighing hair down.
The ingredient is still a niche addition mostly seen in prestige lash and brow serums and a handful of scalp leave-ins. Its use is growing as brands look for gentle alternatives to prescription prostaglandin analogues but it is not yet widespread in mainstream hair care.
Current data shows it is generally safe for topical use with only occasional mild irritation reported. As with any new cosmetic active it is wise to do a small patch test when first trying a product that features this molecule to ensure your skin tolerates it well.