Dipentaerythrityl Hexaisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dipentaerythrityl Hexaisostearate?

Dipentaerythrityl Hexaisostearate is an oil-like ingredient created by joining isostearic acid, a fatty acid often sourced from vegetable oils, with a double unit of the sugar-derived molecule pentaerythritol. The result is a hexaester, meaning six fatty acid chains are linked to one central core, giving the material a silky, cushiony feel that spreads easily on skin.

The cosmetic industry first explored this type of multi-arm ester in the late 1990s when formulators were searching for plant-based options that could mimic the rich texture of mineral oils without the heaviness. Advances in green chemistry soon allowed manufacturers to react purified isostearic acid with pentaerythritol under controlled heat and vacuum, removing water as the reaction progresses. The final step filters and refines the liquid to meet cosmetic-grade standards.

Because it is lightweight yet nourishing, Dipentaerythrityl Hexaisostearate shows up in a wide range of products such as moisturizers, facial oils, sunscreens, lipsticks, foundations, cream blushes, hair styling serums and rinse-off scrubs.

Dipentaerythrityl Hexaisostearate’s Cosmetic Benefits/Uses

Formulators choose this multitasking ester for two main reasons

  • Abrasive: In scrubs and exfoliating masks its smooth round droplets help lift away dead surface cells without scratching, giving skin a polished feel and a soft glow
  • Emollient: The ingredient forms a light breathable film that fills in microscopic gaps between skin cells. This locks in moisture, improves slip during application and leaves a velvety non-greasy finish in creams, lotions and color cosmetics

Who Can Use Dipentaerythrityl Hexaisostearate

For most skin types including dry, normal and combination skin this silky ester offers lightweight moisture without a greasy afterfeel. Sensitive skin generally tolerates it well because it is non fragrant and has a low irritation profile. Very oily or acne-prone complexions can also use it in moderation though extremely occlusive formulas that contain high levels of the ingredient could feel heavy and may contribute to clogged pores in some individuals.

The ingredient is synthesised from plant derived fatty acids and a sugar alcohol so it is accepted by most vegans and vegetarians. Those who follow a strict lifestyle should still verify that the finished product has not been processed with animal derived additives.

Current safety data show no specific risks for people who are pregnant or breastfeeding. Its large molecular size means it stays on the surface of the skin rather than being absorbed into the bloodstream. This is not medical advice and anyone who is pregnant or nursing should review any skincare product with their doctor just to be safe.

Dipentaerythrityl Hexaisostearate does not make skin more sensitive to sunlight and can be used in both day and night products without extra precautions. It is also compatible with most other cosmetic ingredients so it rarely causes formulation conflicts worth noting.

Potential Side Effects/Adverse Reactions

Reactions to topical Dipentaerythrityl Hexaisostearate differ from person to person. The points below outline potential side effects but they are uncommon when the ingredient is used at normal cosmetic levels.

  • Mild skin irritation such as redness or itching in people who are sensitive to fatty esters
  • Contact allergy resulting in small rash patches although documented cases are rare
  • Temporary clogged pores or breakouts if applied in very heavy layers on oily acne-prone skin
  • Stinging or watering if the product accidentally gets into the eyes

If any adverse reaction occurs stop using the product and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 1 / 5

This low rating reflects the ingredient’s branched isostearic structure which makes the oil spreadable yet less likely to sit densely inside pores. Unlike straight chain fatty acids that can build up on the skin surface, Dipentaerythrityl Hexaisostearate forms a light flexible film that is easily removed during cleansing so it rarely triggers congestion in most users.

Because the rating is only a 1, the ester is generally suitable for people who are prone to acne or breakouts though very heavy formulas rich in this ester could still feel too occlusive for extremely oily skin.

Formulation level also matters: rinse-off scrubs typically contain higher percentages but have minimal pore impact while leave-on products use lower amounts that stay comfortable on the skin.

Summary

Dipentaerythrityl Hexaisostearate acts as an emollient that smooths rough texture and as a gentle abrasive carrier in exfoliating products. Its six isostearic acid arms give it silky slip so it fills micro-gaps between skin cells locking in moisture without a greasy feel.

The ester is moderately popular in modern skincare and makeup because it offers a plant-derived alternative to heavier mineral oils while keeping formulations lightweight. You will spot it more often in mid-to-premium ranges where sensorial feel is a selling point.

Current safety data show it to be low risk for irritation or toxicity and its large molecular size limits absorption. As with any new cosmetic ingredient it is wise to perform a quick patch test when trying a product that contains it just to be on the safe side.

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