What Is Dipeptide-29?
Dipeptide-29 is a lab made peptide formed by joining two amino acids, alanine and tryptophan. Peptides like this mimic the tiny protein fragments that occur naturally in skin, which is why they attract attention in skincare labs. First explored in the early 2000s when peptide technology started gaining ground in anti aging research, Dipeptide-29 was developed to give formulators a reliable, stable ingredient that could help keep skin feeling smooth and supple.
Manufacturing begins with synthesizing alanine and tryptophan through standard amino acid production. Chemists then link them in a specific order using solid phase peptide synthesis, a clean process that yields a pure dipeptide free of animal material. The finished powder dissolves easily in water based systems, making it simple to add to creams or serums.
You will most often see Dipeptide-29 in facial moisturizers, anti aging creams, lightweight serums, sheet masks and overnight treatments where a smoother skin feel is a key selling point.
Dipeptide-29’s Cosmetic Benefits/Uses
Dipeptide-29 serves one core role in skincare formulas.
As a skin conditioning agent it supports a soft, hydrated surface by helping products glide on smoothly and leaving behind a silky finish. This can make skin feel more comfortable, reduce the look of dryness and improve overall texture when used regularly.
Who Can Use Dipeptide-29
Dipeptide-29 is generally suitable for all skin types including dry, normal, combination and oily since it is lightweight and non occlusive. Sensitive skin can usually tolerate it well because it has no fragrance or known irritants. There are no specific skin types that must avoid it unless an individual has a confirmed allergy to peptides.
The ingredient is produced entirely through synthetic processes and contains no animal derived components making it appropriate for vegans and vegetarians.
Current data shows no reason to restrict topical Dipeptide-29 during pregnancy or while breastfeeding. That said this information is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding new skincare products to their routine.
Dipeptide-29 does not increase photosensitivity so daytime use does not raise the risk of sunburn though daily sunscreen is still encouraged for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Dipeptide-29 can vary person to person. The points below outline potential issues that, while uncommon, are possible even when the ingredient is used correctly in a well formulated product.
- Mild redness or irritation – most often linked to an individual sensitivity to peptides or another ingredient in the formula
- Temporary itching or tingling – usually subsides quickly as skin adjusts to the product
- Allergic contact dermatitis – rare but can occur in those with a peptide allergy leading to rash swelling or discomfort
- Interaction with other active ingredients – highly unlikely yet very sensitive skin may react when Dipeptide-29 is layered with strong exfoliating acids or retinoids
If any adverse reaction occurs use should be stopped and a healthcare professional consulted
Comedogenic Rating
Rating: 0 / 5
Dipeptide-29 is a small water soluble molecule that does not leave an oily film or linger in pores, so it poses virtually no risk of clogging them. Its job is to condition the skin surface rather than form an occlusive layer, which is why it earns a non-comedogenic score.
Because of this low rating it is considered suitable for people who are prone to acne or breakouts.
Keep in mind the overall formula matters. If Dipeptide-29 is blended into a rich cream loaded with heavier oils the final product could still be comedogenic even though the peptide itself is not.
Summary
Dipeptide-29 is a lab crafted dipeptide that conditions skin, giving products a smoother feel and helping the surface look and feel soft and hydrated. It achieves this by mimicking naturally occurring peptide fragments which support the skin’s own conditioning processes.
The ingredient remains relatively niche compared with headline peptides like Matrixyl yet it appeals to formulators looking for a stable, vegan friendly option that adds a light silky finish without weight or grease.
Current data shows Dipeptide-29 is low risk for irritation, allergy and pore clogging, making it broadly safe for daily use on most skin types. As with any new skincare product, performing a quick patch test before full application is a sensible extra step.