What Is Dipeptide-35?
Dipeptide-35 is a lab made peptide formed by linking two naturally occurring amino acids, glycine and serine. By arranging these building blocks in a precise order scientists create a short chain that the skin can recognize and put to use. The ingredient emerged in the early 2000s when advances in peptide chemistry opened the door to compact molecules that could mimic parts of larger skin proteins. It is produced through solid phase peptide synthesis, a step by step method that attaches protected amino acids to a resin support, then releases and purifies the finished dipeptide for cosmetic use.
Because Dipeptide-35 is lightweight and water soluble it blends easily into many personal care formulas. You will most often see it in anti aging serums, daily moisturizers, eye creams, sheet masks, lightweight gels and concentrated treatment ampoules that aim to boost skin smoothness and resilience.
Dipeptide-35’s Cosmetic Benefits/Uses
Dipeptide-35 serves one main role in skincare formulas: skin conditioning. By helping the surface of the skin stay soft and supple, it can improve overall texture, support a healthy moisture balance and give the complexion a more refreshed look. Regular use may also assist in maintaining a smoother barrier which in turn can enhance the performance of other hydrating or protective ingredients in the same product.
Who Can Use Dipeptide-35
Dipeptide-35 is gentle and water based which makes it suitable for dry, normal, combination and oily skin. Its lightweight nature lets it sink in without a greasy feel so even acne-prone or sensitive skin usually tolerates it well. There are no known concerns that single out any skin type as incompatible.
The peptide is made entirely in a lab from basic amino acids with no animal sourced material. That means products using Dipeptide-35 are generally fit for both vegetarians and vegans as long as the rest of the formula also follows cruelty-free standards.
Current safety data does not flag Dipeptide-35 as a risk for pregnant or breastfeeding women. Still this is not medical advice and anyone who is expecting or nursing should ask their doctor before adding new skincare just to be safe.
Dipeptide-35 has no link to photosensitivity so it will not make the skin more prone to sunburn. Normal daytime sunscreen habits are all that is needed.
Potential Side Effects/Adverse Reactions
Responses to any topical ingredient can vary from person to person. The following are potential side effects that might occur though most users will not experience them if the product has been formulated and used correctly.
- Mild redness or warmth
- Temporary itching
- Light stinging on broken or very dry skin
- Rare allergic rash in those sensitive to peptides
If irritation or another unwanted reaction develops stop using the product and seek advice from a healthcare professional if symptoms do not calm down promptly.
Comedogenic Rating
Rating: 0/5 Dipeptide-35 is a tiny water-soluble molecule that has no oily or waxy residues so it does not sit in pores or create the kind of film that traps dead cells and sebum. Because it is simply two amino acids linked together and used at low concentrations in formulas, it is considered non-comedogenic.
This makes Dipeptide-35 suitable for skin that is prone to acne or frequent breakouts.
Only the overall product texture or the presence of heavier emollients would change pore-clogging potential, not Dipeptide-35 itself.
Summary
Dipeptide-35 conditions the skin by supporting surface proteins, helping moisture stay put and leaving the complexion feeling smoother and more resilient. Its compact structure allows quick absorption and easy pairing with other hydrating agents so formulas can deliver a soft finish without heaviness.
The peptide is still a niche addition rather than a blockbuster ingredient, yet it shows up in select serums, eye creams and sheet masks aimed at gentle skin renewal.
All current research points to a high safety margin with very low irritation risk, but as with any new skincare product a short patch test is a smart precaution.