What Is Dipeptide-39?
Dipeptide-39 is a lab made compound formed by linking two amino acids, asparagine and glutamine. Chemists classify it as a synthetic peptide, a short chain of amino acids designed to copy structures that naturally occur in the skin. The ingredient first drew industry attention in the early 2000s when researchers looked for gentle alternatives to animal derived peptides. By building it entirely in a controlled setting, manufacturers avoid the variability found in natural sources and achieve high purity.
Production starts with individual amino acid building blocks. Through step-by-step reactions the two units are bonded together, then purified with filtration and crystallization until a white, water soluble powder is obtained. Because it is stable in water based formulas and has a neutral scent, formulators can add it without the need for heavy preservatives or masking fragrances.
You will most often see Dipeptide-39 in lightweight moisturizers, anti aging serums, sheet masks, eye creams and leave-on treatments aimed at boosting overall skin comfort.
Dipeptide-39’s Cosmetic Benefits/Uses
Dipeptide-39 is prized for one primary job in skin care.
Skin Conditioning: It helps the skin feel softer and smoother by supporting the natural moisture balance. The peptide structure can signal the surface to retain water more effectively which may reduce the look of dryness and fine lines. In formulas it pairs well with humectants like glycerin to give an immediate silky finish while helping the skin stay hydrated over time.
Who Can Use Dipeptide-39
Dipeptide-39 is gentle enough for most skin types, including normal, dry, oily, combination and sensitive skin. Because it is water soluble and non occlusive it will not leave a heavy film on oily or acne-prone complexions, yet it still offers comfort to drier areas.
The peptide is produced entirely in the lab without animal by-products, making it a suitable option for vegans and vegetarians.
Current data suggests the ingredient poses minimal risk during pregnancy or breastfeeding, but research on topical peptides in these groups is limited. This information is not medical advice and anyone who is pregnant or nursing should discuss new skincare products with a qualified healthcare provider before use.
Dipeptide-39 does not make skin more reactive to sunlight, so it can be applied morning or night. Standard daytime sun protection is still recommended for overall skin health.
The peptide is compatible with most common skincare actives and works across a broad pH range, so it rarely causes conflicts in a routine.
Potential Side Effects/Adverse Reactions
Individual responses to topical Dipeptide-39 can vary. The points below outline potential, not expected, side effects. When formulated and used correctly most people will experience none of these issues.
- Mild redness or irritation on very reactive skin
- Temporary stinging or tingling immediately after application
- Rare cases of allergic contact dermatitis in users sensitive to peptide structures
- Increased sensitivity if layered with highly acidic exfoliants or retinoids in the same routine
Should any unwanted reaction occur stop use and consult a dermatologist or healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Dipeptide-39 is a small, water-soluble molecule that does not leave an oily or occlusive film on the skin, so it is unlikely to clog pores. It lacks fatty acids, waxes or heavy silicones that typically drive comedogenicity, earning it the lowest possible rating.
Because of this it is generally a safe pick for those prone to acne or breakouts.
No data suggest it interferes with sebum flow, and its typical use levels in formulas are very low, further reducing any pore-clogging risk.
Summary
Dipeptide-39 is a lab crafted two-amino-acid peptide that mainly serves as a skin-conditioning agent, helping skin hold on to water and feel smoother. By signaling the surface layers to retain moisture it can soften rough patches and make fine lines look less obvious, especially when paired with classic humectants.
It is still a niche ingredient compared with headline actives like hyaluronic acid or niacinamide, but formulators appreciate its stability, vegan origin and gentle profile, so its presence is slowly growing in modern moisturizers and eye treatments.
Current evidence indicates a very low risk of irritation or pore clogging, making it suitable for most skin types including sensitive and acne-prone. As with any new cosmetic ingredient it is wise to perform a brief patch test when trying a product that contains Dipeptide-39 to ensure your skin agrees with it.