What Is Dipeptide-41 Nicotinate?
Dipeptide-41 Nicotinate is a specialized cosmetic ingredient created by joining niacin, better known as vitamin B3, with a short two-amino-acid peptide called Dipeptide-41. By combining these two molecules, chemists aim to blend the well-known skin benefits of niacin with the targeted action of a peptide, forming a single compound that skin can recognize and use easily.
The concept grows out of decades of research on both peptides and niacin in skincare. Peptides have been praised since the early 2000s for helping skin look firmer while niacin has a longer history of supporting an even tone and healthy barrier. Marrying the two in one molecule is a relatively recent step that allows brands to streamline formulas and cut down on extra additives.
Manufacturing starts with laboratory synthesis of the peptide chain, followed by a controlled reaction where niacin is bonded to the peptide’s end. The process is done in sterile, temperature-regulated vessels and then purified so only the finished Dipeptide-41 Nicotinate remains.
You will most often find this ingredient in anti-aging serums, lightweight moisturizers, night creams, sheet masks, eye treatments and leave-on lotions aimed at smoothing or firming the skin.
Dipeptide-41 Nicotinate’s Cosmetic Benefits/Uses
In topical products Dipeptide-41 Nicotinate is valued for one main job.
Skin conditioning: Once applied it helps keep the surface of the skin soft, supple and hydrated. The peptide segment can signal skin to look firmer while niacin supports a stronger moisture barrier and a more even appearance. Together they leave skin feeling smoother, looking refreshed and better able to hold on to water throughout the day.
Who Can Use Dipeptide-41 Nicotinate
Dipeptide-41 Nicotinate is generally suitable for all skin types including oily, combination, dry and mature skin. Sensitive skin usually tolerates it well because the peptide portion is gentle, though very reactive skin may notice a quick flush thanks to niacin’s circulation-boosting nature.
The ingredient is produced through laboratory synthesis with no animal-derived components so it is appropriate for both vegans and vegetarians. Always confirm the finished product’s full ingredient list and brand policy on animal testing if that is a concern.
No warnings specific to pregnancy or breastfeeding have been issued for topical use of this compound. That said this is not medical advice and anyone who is pregnant or nursing should show the product to their healthcare provider before use just to be safe.
Dipeptide-41 Nicotinate is not known to cause photosensitivity. Normal daytime sun protection practices still apply, especially when using any skin-conditioning or anti-aging routine.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Dipeptide-41 Nicotinate can vary from person to person. The points below cover potential issues yet most users will not experience them when the ingredient is formulated and used correctly.
- Temporary warmth or flushing in the area of application
- Mild redness or irritation, especially on very sensitive skin
- Itching or tingling that subsides within minutes
- Rare allergic contact dermatitis presenting as persistent redness, bumps or swelling
- Increased irritation if layered with strong exfoliating acids or retinoids in the same routine
If any uncomfortable reaction develops stop using the product and seek advice from a qualified healthcare professional.
Comedogenic Rating
Rating: 0–1 (non-comedogenic to very low)
Dipeptide-41 Nicotinate is a small, water-soluble molecule with no heavy oils or waxes that could clog pores. The peptide-niacin structure is designed to penetrate quickly and does not leave an occlusive film on the skin. Because of this lightweight profile formulators consider it non-comedogenic or at most very low on the scale.
That makes it generally suitable for acne-prone or breakout-prone skin.
As with any ingredient, the final product’s full formula matters. If Dipeptide-41 Nicotinate appears in a rich cream loaded with butters or certain silicones the overall product could still trigger congestion even though the peptide itself is pore-friendly.
Summary
Dipeptide-41 Nicotinate conditions the skin by pairing a signaling peptide with niacin, helping the surface stay soft and hydrated while subtly supporting firmness and a more even tone. The peptide cues skin for a smoother look and the niacin strengthens the moisture barrier.
It is not yet a household name like retinol or hyaluronic acid, appearing mainly in niche anti-aging serums and advanced moisturizers, but interest is growing as brands look to combine multiple benefits in streamlined formulas.
Current data show it is safe for most people with only mild, short-lived flushing or irritation reported in sensitive users. As with any new skincare ingredient do a quick patch test before applying it to the entire face to make sure your skin agrees with it.