Diphylleia Grayi Callus Extract: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Diphylleia Grayi Callus Extract?

Diphylleia Grayi Callus Extract comes from the callus tissue of the rare skeleton flower, Diphylleia grayi, a small woodland plant known for petals that turn transparent when wet. Instead of harvesting wild plants, scientists take a tiny piece of the leaf and grow it in a sterile laboratory setting called plant cell culture. This approach yields a stable, sustainable supply while protecting the species in nature.

The cultured cells are rich in protective molecules the plant makes for itself, notably polyphenols, flavonoids and organic acids. These compounds give the extract its antioxidant, antimicrobial and astringent traits and help it soothe and protect skin and hair.

Interest in the skeleton flower rose in the 2010s as Korean beauty brands searched for eye-catching botanical stories. Plant cell culture technology allowed formulators to tap into the plant’s bioactive profile without environmental impact. Once grown to a dense mass, the cells are broken down, filtered and concentrated to form a water-soluble extract that is easy to add to cosmetic bases.

You will most often find Diphylleia Grayi Callus Extract in lightweight serums, anti aging creams, brightening essences, hydrating sheet masks, soothing toners, scalp tonics and conditioning hair treatments where it supports overall formula stability and sensory feel.

Diphylleia Grayi Callus Extract’s Cosmetic Benefits/Uses

This multitasking botanical brings several helpful actions to skin and hair care formulas

  • Antimicrobial: Helps keep products fresher longer by curbing the growth of bacteria, yeast and mold and can support clearer looking skin by reducing surface germs
  • Antioxidant: Neutralizes free radicals generated by sun exposure and pollution which may help soften the look of fine lines and dullness
  • Astringent: Provides a mild tightening effect that can temporarily refine the appearance of pores and give skin a smoother feel
  • Hair Conditioning: Forms a light protective film on strands to improve slip, add softness and boost shine without added weight
  • Skin Conditioning: Contributes a comforting, hydrated finish leaving skin feeling smooth and supple

Who Can Use Diphylleia Grayi Callus Extract

Diphylleia Grayi Callus Extract is generally well tolerated by all skin types including oily, dry, combination and sensitive skin thanks to its lightweight water soluble profile and soothing plant antioxidants. Those with very dry or eczema prone skin may want to pair it with richer emollients since its mild astringent action can feel lightly tightening on its own.

The extract is produced from plant cells in a controlled laboratory setting without animal derived materials so it is suitable for vegans and vegetarians.

There are no reports of hormonal activity so pregnant or breastfeeding individuals can usually use products containing this extract, but this is not medical advice and anyone expecting or nursing should confirm every skincare choice with their doctor first.

Diphylleia Grayi Callus Extract does not increase photosensitivity and can be used morning or night alongside regular sun protection.

Potential Side Effects/Adverse Reactions

Responses to topical Diphylleia Grayi Callus Extract differ from person to person. The effects listed below are only potential outcomes and are unlikely to occur for most users when the ingredient is formulated and used correctly.

  • Redness or mild irritation in very sensitive skin
  • Temporary stinging if applied to freshly exfoliated or broken skin
  • Dry or tight feeling in users already prone to dehydration
  • Allergic contact dermatitis in individuals allergic to plants from the Berberidaceae family

If any unwanted reaction develops stop use immediately and seek medical advice if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 / 5

Diphylleia Grayi Callus Extract is a water based ingredient with no heavy oils or waxes so it does not leave an occlusive film that could trap dead cells inside pores. Its antioxidant and mild astringent properties can actually help keep skin surface balanced and less prone to congestion. For these reasons it earns the lowest possible comedogenic score.

That makes it a friendly option for people who experience acne or frequent breakouts.

Formulators often pair this extract with other lightweight humectants which helps maintain its non clogging profile when blended into finished products.

Summary

Diphylleia Grayi Callus Extract offers antimicrobial, antioxidant, astringent, hair conditioning and skin conditioning benefits thanks to plant made polyphenols and flavonoids that defend against microbes and free radicals while giving a light tightening feel. In formulas it boosts product stability, leaves skin smoother and adds slip and shine to hair.

The ingredient enjoys moderate popularity in K beauty inspired skincare although it is still a niche botanical outside that circle. Brands appreciate its sustainable lab grown sourcing and the skeleton flower story gives an eye catching marketing angle.

Overall it is considered safe for most users with very low risk of irritation or pore blockage. As with any new cosmetic ingredient it is smart to do a quick patch test when trying a product that contains it especially if you have reactive skin.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search