Disodium Hydroxyethyliminodiacetate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Disodium Hydroxyethyliminodiacetate?

Disodium Hydroxyethyliminodiacetate is a synthetic ingredient derived from combining salts of acetic acid with a small alcohol-based molecule known as hydroxyethyl imino. Chemically it is categorized as a chelating agent, meaning it latches onto metal ions such as iron or calcium that can be present in water and raw materials. The compound was first explored in the mid-20th century when formulators sought safer, more environmentally friendly alternatives to older chelators like EDTA. Modern production starts with reacting monochloroacetic acid with hydroxyethylamine then neutralizing the mixture with sodium hydroxide, resulting in the disodium salt that is stable and water-soluble. Because of its ability to improve product stability and appearance, Disodium Hydroxyethyliminodiacetate is often found in facial cleansers, shampoos, conditioners, serums, sheet masks, sunscreens, anti-aging creams and even color cosmetics such as liquid foundations.

Disodium Hydroxyethyliminodiacetate’s Cosmetic Benefits/Uses

In formulas this ingredient plays a single but important role.

As a chelating agent it binds trace metals that can otherwise trigger discoloration, rancidity or texture changes. By controlling these metals it helps keep fragrances true, prevents oils from going stale and allows preservatives to work more efficiently, which ultimately extends the shelf life and ensures the product looks and feels the same from the first use to the last.

Who Can Use Disodium Hydroxyethyliminodiacetate

This chelating agent is considered gentle enough for all skin types, including dry, oily, combination and sensitive skin, because it does not sit on the surface or clog pores and works at very low concentrations. There are no known reasons for people with acne-prone or mature skin to avoid it.

Because the compound is fully synthetic and not sourced from animals it is suitable for vegans and vegetarians. Production does not rely on animal by-products or animal testing in most regions that follow modern cosmetic regulations.

Current safety data indicate that Disodium Hydroxyethyliminodiacetate is unlikely to pose a risk to women who are pregnant or breastfeeding when used in normal cosmetic amounts. This is not medical advice; anyone who is pregnant or nursing should review all skincare products with a qualified health professional to be sure they meet individual needs.

The ingredient does not absorb UV light or make skin more reactive to sunlight, so it does not cause photosensitivity. It is also fragrance-free and colorless, making it a low-profile addition to formulas for people who prefer minimal extras.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical use of Disodium Hydroxyethyliminodiacetate can vary from person to person. The following is a list of potential effects, most of which are uncommon when the ingredient is used correctly in finished products.

  • Mild skin irritation – a temporary stinging or itching sensation, typically in those with very sensitive or compromised skin
  • Redness or flushing – localized warmth or color change that usually subsides once the product is rinsed off
  • Allergic contact dermatitis – rare but possible rash in individuals with a specific allergy to chelating agents
  • Eye irritation – watering or burning if a product containing the ingredient accidentally gets into the eyes

If any of these side effects occur stop using the product and consult a healthcare professional for further guidance.

Comedogenic Rating

Rating: 0/5

Disodium Hydroxyethyliminodiacetate is water-soluble and works at very low levels, so it rinses away easily and does not sit inside pores. It has no oily or waxy parts that would thicken on the skin and trap debris. Because of this it earns the lowest possible comedogenic score.

Its lack of pore-clogging traits makes it suitable for people who are prone to acne or frequent breakouts.

No special factors are known that would raise its comedogenic potential even when used alongside heavier ingredients.

Summary

Disodium Hydroxyethyliminodiacetate is used in cosmetics as a chelating agent. It grabs onto trace metals like iron and calcium, keeping them from spoiling fats, fading colors or weakening preservatives. By removing those metals it helps products stay fresh look the right color and keep the same texture across their shelf life.

While not a household name it is gaining steady use in cleansers, serums, hair care and makeup because formulators appreciate its mildness and eco-friendlier profile compared with older chelators.

Current research shows it to be safe for all skin types with very low risk of irritation. As with any new skincare item it is smart to patch test first to check personal tolerance.

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