Disodium Isostearoamphodiacetate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Disodium Isostearoamphodiacetate?

Disodium Isostearoamphodiacetate is a synthetic surfactant derived from isostearic acid, a fatty acid that can be sourced from plant oils such as rapeseed or soybean. Chemically it belongs to the amphoteric surfactant family, meaning it can carry either a positive or negative charge depending on the pH of its surroundings. Manufacturers react isostearic acid with amino acids, then neutralize the mixture with sodium salts, creating a water-soluble powder or liquid that blends easily into cosmetic bases.

The ingredient gained popularity in the late 1990s when formulators sought milder, more versatile alternatives to traditional sulfates. Its balanced cleansing action and skin friendly profile made it a staple in gentle shampoos and facial washes. Today it is produced in large batches through controlled condensation reactions performed at moderated temperatures to preserve its mildness. After synthesis the raw material is filtered, standardized for purity and packaged for use in cosmetics.

You’ll most often spot Disodium Isostearoamphodiacetate in sulfate-free shampoos, micellar facial cleansers, baby washes, liquid hand soaps, bubble baths and some leave-in hair conditioners. Because it helps stabilize foam and improve rinse-off it also appears in clay masks, shower gels and even a few lightweight body lotions designed for quick absorption.

Disodium Isostearoamphodiacetate’s Cosmetic Benefits/Uses

This multi-tasking ingredient supports several aspects of a formula’s performance

  • Cleansing: Lifts away dirt, oil and product buildup without stripping natural moisture, making products feel gentle yet effective
  • Foaming: Creates a rich, stable lather that enhances the sensory experience in shampoos and body washes
  • Hair Conditioning: Deposits a light film on strands that smooths cuticles, reduces static and improves combability
  • Foam Boosting: Works alongside primary surfactants to increase foam volume and density so less product is needed for the same cleansing power
  • Hydrotrope: Helps dissolve other ingredients that might otherwise separate, keeping formulations clear and uniform over time

Who Can Use Disodium Isostearoamphodiacetate

Disodium Isostearoamphodiacetate is generally considered suitable for all skin types including normal, oily, dry, sensitive and mature. Its mild, amphoteric nature means it cleans without aggressively stripping natural moisture so even easily irritated skin usually tolerates it well. It is not known to clog pores which makes it appropriate for acne-prone users too.

The ingredient is synthesized from plant-derived fatty acids and neutralized with mineral salts, giving it a vegan and vegetarian friendly profile. No animal by-products or animal testing are required in its standard production pathway.

Current safety data indicate no specific risks for pregnant or breastfeeding women when the ingredient is used at the low concentrations typical in cosmetics. That said this information is not medical advice; anyone who is pregnant or nursing should check any skincare product with a qualified healthcare professional to be sure it aligns with their personal situation.

Disodium Isostearoamphodiacetate does not increase photosensitivity so users do not need extra sun protection beyond their usual SPF habits. Because it is readily biodegradable and regarded as low toxicity it is also considered environmentally gentle compared with some conventional surfactants.

Potential Side Effects/Adverse Reactions

Responses to topical Disodium Isostearoamphodiacetate can vary from person to person. The points below outline potential side effects which are uncommonly reported and should not reflect the experience of most users when the ingredient is properly formulated and used.

  • Mild skin irritation such as redness or itching, typically in individuals with compromised skin barriers
  • Transient eye stinging if the product accidentally enters the eyes during use
  • Allergic contact dermatitis in rare cases where a user is sensitized to the ingredient or other formula components
  • Dryness or tight feel if the product is overused or left on the skin longer than directed

If any discomfort, persistent redness or swelling occurs discontinue use and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 0

Disodium Isostearoamphodiacetate is water soluble and rinses off easily, leaving very little residual film on skin. Unlike heavier fatty acids or oils it does not occlude pores, which is why formulators consider it non-comedogenic.

Suitable for acne-prone and breakout-prone skin.

Because it helps dissolve excess sebum in cleansers it can actually assist in keeping pores clear when part of a well-balanced formula.

Summary

Disodium Isostearoamphodiacetate is a mild amphoteric surfactant that cleanses, boosts foam, conditions hair, stabilizes formulas and acts as a hydrotrope by surrounding oil and dirt so they can be rinsed away with water. Its balanced charge lets it perform these tasks without stripping skin or hair.

The ingredient is moderately popular in sulfate-free shampoos, gentle face washes and baby cleansers, though it is still less mainstream than classic sulfates or glucosides.

Current safety data show a very low risk of irritation or sensitization when used at the levels found in cosmetics. As with any new product it is wise to carry out a quick patch test to make sure your skin responds well.

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