Disodium Phenylene Bis-Isostearylphosphate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Disodium Phenylene Bis-Isostearylphosphate?

Disodium Phenylene Bis-Isostearylphosphate, sometimes shown on labels as Disodium Diisostearyl Hydroquinone Diphosphate, is a lab crafted ingredient that links a phenylene core to two isostearyl phosphate groups. The isostearyl segments come from isostearic acid, a fatty acid usually sourced from vegetable oils like rapeseed or soybean, while the phosphate part is derived from phosphorus based reagents. By joining these parts chemists create a molecule that combines the feel of a lightweight oil with the stability offered by phosphate chemistry.

The ingredient emerged in the early 2000s when formulators were looking for alternatives to heavier plant butters and silicones. Its balanced structure gives the slip of an oil yet leaves a non greasy finish, which quickly made it popular in modern skincare. Production involves reacting isostearic acid with phosphorus oxychloride to form isostearyl phosphate, then linking two of these units to a phenylene diol under controlled conditions. Finally neutralization with sodium hydroxide gives the disodium salt that is water dispersible.

You will often see Disodium Phenylene Bis-Isostearylphosphate in silky facial moisturizers, anti aging serums, tinted creams, sheet masks, leave on night treatments and even some lip balms. Brands choose it when they want a nourishing feel without a heavy residue.

Disodium Phenylene Bis-Isostearylphosphate’s Cosmetic Benefits/Uses

This ingredient brings a couple of useful perks to skin care formulas

  • Skin conditioning – it softens the surface of the skin, leaving it smoother and more supple after application. The fatty isostearyl chains mimic natural skin lipids so the product feels comfortable and helps maintain moisture
  • Emollient – it fills in microscopic gaps between skin cells which reduces rough texture and boosts the overall glide of a cream or serum. This results in a product that spreads easily and leaves a lightweight, velvety finish

Who Can Use Disodium Phenylene Bis-Isostearylphosphate

Most skin types can enjoy this ingredient. Its lightweight buttery feel suits normal, dry and combination skin that needs softness without a greasy aftertouch. Oily and acne prone users often tolerate it as well because it has a low tendency to clog pores, though extremely breakout-prone individuals may still prefer to spot check new formulas. Sensitive skin usually gets along with it because it lacks harsh acids or fragrances.

Disodium Phenylene Bis-Isostearylphosphate is produced from vegetable-derived isostearic acid and mineral phosphorus sources so it is considered suitable for vegans and vegetarians. No animal-based raw materials or by-products are involved in standard manufacturing.

Current data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used in rinse-off or leave-on cosmetics. Still this is not medical advice and anyone who is expecting or nursing should share their full skincare lineup with a qualified health professional to be safe.

The molecule does not absorb UV light and is not known to trigger photosensitivity. It also plays well with common actives like vitamin C, niacinamide and gentle exfoliating acids, making it easy to slot into most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Disodium Phenylene Bis-Isostearylphosphate differ from person to person. The points below cover possible effects yet most users will not notice any problems when the ingredient is properly formulated and used as directed.

  • Mild skin redness or itching in extremely sensitive individuals
  • Transient stinging if applied to cracked or freshly exfoliated skin
  • Very rare contact allergy leading to localized rash
  • Potential pore congestion in users already prone to comedones when layered with many rich oils or occlusive products

If any discomfort or unusual reaction develops stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. The bulky branched isostearyl chains form a thin, breathable layer rather than a heavy film so they rarely trap debris inside pores. Lab and user reports show little tendency to trigger whiteheads or blackheads, though a faint risk remains for highly reactive skin.

With this low rating the ingredient is generally considered safe for acne-prone users.

If a product also contains dense butters or waxes the overall formula could be more pore-clogging, so check the full ingredient list when in doubt.

Summary

Disodium Phenylene Bis-Isostearylphosphate acts as both an emollient and a skin conditioner, leaving skin soft, smooth and comfortably moisturized. Its fatty tails mimic natural lipids while the phosphate backbone keeps the texture light and stable, helping formulas glide on effortlessly and set to a velvety finish.

Although not yet a household name it has carved out a spot in many modern moisturizers, serums and tinted products where a silky feel is prized over a greasy one.

Current research shows it to be low risk for irritation or pore blockage in most users, but skin is personal so do a quick patch test with any new product that features this ingredient just to play it safe.

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