Disodium Phloretin Disulfonate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Disodium Phloretin Disulfonate?

Disodium Phloretin Disulfonate is a water soluble salt derived from phloretin, a natural flavonoid that occurs in apple tree bark and some other fruit plants. Chemists modify phloretin by attaching two sulfonate groups, then neutralize the molecule with sodium to make it stable and easy to blend into water based formulas. This tweak keeps the antioxidant core of phloretin intact while improving its solubility, which is why the disulfonate form has become a favorite for modern skincare labs. The ingredient first appeared in research focused on reducing oxidative stress in skin, and it entered commercial cosmetics in the early 2010s when brands began looking for gentle plant inspired protectors that work well in lightweight products. Production starts with purified phloretin extracted from plant material, followed by controlled sulfonation in a lab setting and a final purification step to remove by products. You will most often find Disodium Phloretin Disulfonate in serums, day creams, anti-aging moisturizers, brightening essences, after-sun lotions and sheet masks where formulators want a clear non greasy texture with added skin defense.

Disodium Phloretin Disulfonate’s Cosmetic Benefits/Uses

As a skin protecting agent Disodium Phloretin Disulfonate helps shield the skin surface from daily environmental stress such as pollution and light exposure. By scavenging free radicals it supports the skin’s own barrier, which can translate to a fresher tone, less visible dullness and an overall healthier look when used consistently in a routine.

Who Can Use Disodium Phloretin Disulfonate

This ingredient is gentle enough for every skin type including oily, combination, dry and sensitive because it is water based and free of heavy oils or fragrances. It rarely triggers excess oil or clogs pores, so acne-prone users usually tolerate it well. People with extremely reactive skin should still stay mindful of any formula extras such as fragrances or alcohol that might be present in the finished product rather than the active itself.

Disodium Phloretin Disulfonate is sourced from plant material and processed without animal derivatives which makes it a suitable choice for vegans and vegetarians.

Current safety data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically in normal cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should consult a healthcare professional before adding new skincare to their routine just to be safe.

The ingredient does not increase photosensitivity. In fact its antioxidant action can help defend skin during daylight hours although daily sunscreen is still essential for overall protection.

Potential Side Effects/Adverse Reactions

Side effects or reactions to topical Disodium Phloretin Disulfonate vary from person to person. The points below outline potential issues yet most users will not experience them when the ingredient is included in a properly formulated product.

  • Mild transient stinging on very sensitive or freshly exfoliated skin
  • Light redness or flushing if the formula contains additional irritating substances
  • Rare allergic contact dermatitis for individuals sensitive to flavonoid derivatives
  • Discoloration of the product or slight smell change if stored in extreme heat which may hint at reduced potency

If any irritation or unusual change in the skin occurs discontinue use and seek advice from a qualified medical professional.

Comedogenic Rating

Rating: 0

Disodium Phloretin Disulfonate is entirely water soluble and contains no heavy oils, waxes or fatty acids that could lodge inside pores. Its molecular size is small enough to rinse away easily yet not so small that it penetrates deep into sebaceous follicles where clogging tends to start. Finished formulas that feature this ingredient are usually lightweight serums or gels rather than occlusive creams, further lowering any pore blocking risk.

Because of these factors it is suitable for people who are prone to acne or frequent breakouts.

Summary

Disodium Phloretin Disulfonate works as a skin protecting antioxidant, neutralizing free radicals that form from pollution, blue light and UV exposure. By reducing oxidative stress it helps maintain a brighter, healthier looking complexion and supports the skin’s natural barrier so moisture is lost more slowly.

The ingredient is gaining traction with forward thinking brands that want plant derived actives for clear, fast absorbing formulas, though it is not yet as common as classic antioxidants like vitamin C or green tea extract.

Current research and cosmetic use show it to be very safe for topical application with a low likelihood of irritation or sensitization. Still, everyone’s skin is unique so it is wise to perform a quick patch test when trying a new product that includes Disodium Phloretin Disulfonate.

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