Dmso: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dmso?

Dmso, short for dimethyl sulfoxide, is an organosulfur compound that started out as a by-product of the wood pulp industry. Chemically it consists of a sulfur atom bonded to two methyl groups and one oxygen atom, giving it a polar yet relatively small structure that mixes well with both water and many oils. The material is produced on an industrial scale by oxidizing dimethyl sulfide, itself derived from lignin in wood. After purification the clear, nearly odorless liquid becomes the Dmso used in personal care.

Its path into cosmetics began in the 1960s when researchers noticed how easily Dmso carried other substances through the skin. While early excitement focused on pharmaceutical delivery, formulators soon saw value in the solvent power alone. Today you might spot Dmso in specialty serums, masks, intensive moisturizers, exfoliating treatments and some anti-aging formulas where it helps keep tricky actives in solution.

Dmso’s Cosmetic Benefits/Uses

In topical beauty products Dmso serves a single but important purpose.

Solvent: Dmso dissolves a wide range of water-soluble and oil-soluble ingredients, allowing formulators to blend vitamins, botanical extracts and other actives that otherwise separate or crystallize. By keeping these components evenly dispersed it improves texture, stability and the overall effectiveness of the finished product.

Who Can Use Dmso

Dmso is generally best for normal and combination skin that can handle a strong solvent. Oily skin often tolerates it as well since the ingredient is not greasy and cuts through excess sebum. Sensitive or very dry skin may find it too assertive because its high penetration power can strip natural lipids and cause sting or redness. People with broken or compromised skin barriers should steer clear since Dmso will move other substances deeper than intended.

The compound is synthetic and made from wood-derived raw materials so it suits both vegans and vegetarians. No animal by-products or testing are required for its manufacture.

Current research has not flagged specific issues for topical Dmso during pregnancy or breastfeeding, yet absorption through the skin is significant. This is not medical advice and pregnant or nursing individuals should ask a doctor before using any product containing Dmso to be safe.

Dmso does not heighten photosensitivity and will not make skin more prone to sunburn. It does have a distinct garlic-like odor that can appear on the breath for a few hours after use which some users may find off-putting.

Potential Side Effects/Adverse Reactions

Responses to topical Dmso differ widely. The points below outline possible side effects but most people using a well-formulated product will not run into these issues.

  • Skin irritation mild burning tingling or warmth may appear especially on sensitive skin
  • Dryness or flaking the solvent action can pull water and oils from the surface leaving skin tight
  • Redness and swelling temporary erythema can occur if concentration is high or skin barrier is weak
  • Allergic contact dermatitis rare but possible presenting as itchy rash or blisters
  • Garlic-like breath and body odor systemic absorption can convert Dmso into dimethyl sulfide which exits via lungs and sweat glands
  • Headache dizziness or nausea very uncommon systemic effects reported when large areas are treated frequently
  • Enhanced absorption of other actives or drugs may raise potency and risk of irritation from ingredients that are normally mild

If any adverse reaction occurs stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 0/5. Dmso is a lightweight polar solvent that penetrates or evaporates quickly without leaving an occlusive film, so it does not block pores. Instead it can thin sebum, helping keep follicles clear.

This makes the ingredient generally suitable for acne-prone or breakout-prone skin.

Keep in mind its penetration boost can draw other, more comedogenic ingredients deeper, so overall formula choice still matters.

Summary

In cosmetic formulas Dmso works mainly as a powerful solvent, holding both water-soluble and oil-soluble actives in a smooth stable blend. Its small polar structure lets it slip through the skin’s outer layers and escort those actives along, which can improve product performance and feel.

The ingredient remains a niche pick rather than a chart-topping beauty star, partly because of its distinctive odor and the regulatory care required around its high absorption rate.

Used at sensible levels Dmso is generally safe, with most users experiencing no more than mild transient dryness or warmth. Still, skin types vary, so patch testing any new product that contains Dmso is a smart precaution.

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