What Is Ethyl Carbazido Hyaluronate Rh-Polypeptide-3?
Ethyl Carbazido Hyaluronate Rh-Polypeptide-3 is a lab crafted hybrid of two well known skin care favorites: hyaluronic acid and signal peptides. Chemists start with hyaluronic acid that has been produced by safe bacterial fermentation. They attach small ethyl carbazide groups to parts of the hyaluronic acid chain, which helps the molecule cling to water while resisting quick breakdown on the skin. This modified hyaluronate is then linked to Rh-Polypeptide-3, a laboratory made string of amino acids that mirrors naturally occurring skin peptides. The result is a single ingredient that pairs the deep hydration of hyaluronic acid with the skin supporting activity of peptides.
The technology behind it is fairly new. Advances in peptide synthesis and cleaner fermentation methods in the past decade opened the door for combining large sugar molecules with precise peptide sequences. Brands first added the complex to premium anti aging serums before it trickled into masks, eye creams, moisturizers and after sun treatments.
Manufacturing involves three main steps: fermentation to create pure hyaluronic acid, chemical modification with ethyl carbazide under controlled pH, and gentle coupling of the modified acid to Rh-Polypeptide-3 followed by filtration and drying. Each batch is tested to confirm peptide content and low levels of impurities.
Ethyl Carbazido Hyaluronate Rh-Polypeptide-3’s Cosmetic Benefits/Uses
In formulas this dual action ingredient works hard on two fronts
- Humectant: It pulls moisture from the air and deeper skin layers to the surface, giving an instant plumping effect and helping creams feel pleasantly dewy rather than greasy. Consistent use supports a smoother look by keeping the upper skin layers hydrated.
- Antioxidant: The peptide portion helps neutralize free radicals created by UV light and pollution. This extra defense may slow the look of premature aging such as fine lines or dull tone when used alongside sunscreen and other protective steps.
Who Can Use Ethyl Carbazido Hyaluronate Rh-Polypeptide-3
This moisture loving antioxidant suits nearly every skin type from dry and mature to oily and combination because it is lightweight and non occlusive. Sensitive skin generally tolerates it well thanks to its gentle nature but anyone with a known allergy to hyaluronic acid or peptides should proceed cautiously.
The compound is produced through bacterial fermentation and synthetic peptide assembly so it contains no animal derived materials. That makes it appropriate for both vegans and vegetarians.
Current data indicates no specific risk for pregnant or breastfeeding women when the ingredient is used topically in normal cosmetic concentrations. Even so this is not medical advice and anyone who is expecting or nursing should show the full product ingredient list to a healthcare professional before use just to be safe.
Ethyl Carbazido Hyaluronate Rh-Polypeptide-3 does not increase photosensitivity. Standard daytime sun protection is still recommended but there is no special need to avoid sunlight because of this ingredient.
Potential Side Effects/Adverse Reactions
Reactions to topical Ethyl Carbazido Hyaluronate Rh-Polypeptide-3 vary from person to person. The points below list potential side effects although most users will not experience them when the ingredient is correctly formulated and applied.
- Mild redness or flushing brief warmth or color change as the product absorbs
- Itching or tingling usually temporary and more common on compromised skin
- Dry patches rare paradoxical dryness if the formula lacks enough occlusive agents in very low humidity environments
- Allergic contact dermatitis localized rash in individuals sensitive to hyaluronic modifiers or specific peptide sequences
- Interaction with highly acidic or exfoliating products possible irritation when layered with strong AHAs or BHAs
If any persistent or severe reaction occurs discontinue use and consult a medical professional.
Comedogenic Rating
Rating: 0–1. Ethyl Carbazido Hyaluronate Rh-Polypeptide-3 is a large water-binding molecule with no oily or waxy residues so it does not sit inside pores or create the film that typically triggers clogs. The peptide chain is water soluble and the ethyl carbazide modification is minimal, keeping overall stickiness low. In real-world formulas the ingredient is usually used at low concentrations alongside lightweight gel or lotion bases, further reducing any risk of pore blockage.
Because of this low score it is generally suitable for acne-prone or breakout-prone skin.
One extra point: a formula that pairs this ingredient with heavy butters or thick silicones could still feel occlusive, so always look at the whole ingredient list rather than judging by a single component.
Summary
Ethyl Carbazido Hyaluronate Rh-Polypeptide-3 acts as a humectant and antioxidant. The modified hyaluronic acid attracts and holds moisture, giving skin a plump hydrated look, while the attached peptide helps mop up free radicals created by stressors like UV light and pollution. Together they support a smoother bouncier complexion with added environmental defense.
The complex is still a niche player compared with classic hyaluronic acid or standalone peptides, yet its dual action profile is earning it spots in more mid to high tier serums masks and eye creams.
Safety data so far is reassuring: it is non comedogenic, vegan friendly and well tolerated by most skin types. Even so skin can be unpredictable, so it is wise to do a quick patch test whenever you bring a new product containing this ingredient into your routine.