What Is Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95?
Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95 is a lab-designed fusion peptide attached to a modified form of hyaluronic acid. Scientists start by stitching together the DNA sequences that code for several naturally occurring signal peptides then insert this custom gene into Chinese hamster ovary (CHO) cells. As the cells grow in a fermenter they produce a single chain protein that is later purified and chemically linked to ethyl carbazido hyaluronate. This hyaluronate not only stabilizes the peptide but also helps it spread easily on skin.
The ingredient emerged from the ongoing search for gentle yet effective anti-aging actives. Advances in recombinant technology during the early 2000s made it possible to create hybrid peptides with targeted skin benefits. Pairing the peptide with a hyaluronic backbone offered an extra boost of moisture and helped deliver the protein more evenly across the skin surface. Since then formulators have adopted it in premium skincare lines that focus on protection and repair.
You are most likely to find this peptide in lightweight serums, sheet masks, moisturizing lotions, post-sun soothing gels and high-performance anti-aging creams where it plays a supportive role next to antioxidants and humectants.
Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95’s Cosmetic Benefits/Uses
In topical products this ingredient serves one key purpose that brings several visible perks to your routine.
Skin protecting: By forming a thin breathable film on the surface the peptide-hyaluronate complex helps shield skin from everyday environmental stress such as pollution and dry air. The protective layer supports the skin barrier so moisture stays in longer and sensitivity is less likely to flare. Over time consistent use can leave the complexion looking calmer smoother and better hydrated.
Who Can Use Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95
This peptide-hyaluronate complex is generally suitable for all skin types including dry oily combination and sensitive skin because it is lightweight and non-greasy while supplying barrier support. People with a known allergy to hyaluronic acid or peptides should avoid it as irritation could occur.
The ingredient is produced in Chinese hamster ovary cells so it is technically animal-derived and therefore may not meet strict vegan or vegetarian standards despite being used only in the laboratory setting.
Current data suggests that topical use during pregnancy or while breastfeeding poses a very low risk because the molecule is large and stays near the skin surface. That said this is not medical advice and anyone who is pregnant or nursing should show the full product label to a healthcare professional before use to be safe.
The peptide does not increase photosensitivity so it can be used morning or night without raising the risk of sunburn. It also layers well with most actives such as niacinamide retinoids and vitamin C.
Potential Side Effects/Adverse Reactions
Responses to topical Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95 vary from person to person. The effects listed below are possible yet uncommon when the ingredient is properly formulated.
- Transient redness or warmth
- Mild stinging or tingling on application
- Localized itching or rash in those sensitive to peptides or hyaluronate
- Contact dermatitis in individuals with a specific allergy to any component
- Clogged pores or small breakouts if used in an overly occlusive formula
If you notice persistent discomfort swelling or any severe reaction stop using the product immediately and consult a medical professional.
Comedogenic Rating
Rating: 0-1 (very low). This peptide-hyaluronate complex is large and water-loving so it stays on the skin surface instead of slipping into pores. It contains no heavy oils or waxes that normally lead to congestion, making it highly unlikely to clog pores.
That means it is generally safe for acne-prone or breakout-prone skin.
Remember that the rest of a product’s formula can still influence pore clogging. Rich butters, waxes or silicones in the same product may raise comedogenic potential even though the peptide itself does not.
Summary
Ethyl Carbazido Hyaluronate Sh-Oligopeptide-1 Sh-Polypeptide-94 Dipeptide-35 Sh-Polypeptide-94 Sh-Polypeptide-95 works as a skin-protecting active. The hyaluronic portion draws and locks in moisture while the recombinant peptide forms a thin protective film and sends calming signals that support a stronger barrier. Consistent use can lead to smoother, calmer and better-hydrated skin.
The ingredient is still a niche addition, most often showing up in premium serums, creams and sheet masks rather than in mass-market formulas, but it is slowly gaining traction with brands that value gentle barrier support.
Overall safety data are reassuring with low rates of irritation or sensitization. Still, it is always wise to patch test any new product containing this ingredient to ensure your skin responds well.