Ethyl Dicarboethoxy Pantothenate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Ethyl Dicarboethoxy Pantothenate?

Ethyl Dicarboethoxy Pantothenate is a lab-crafted derivative of vitamin B5, also known as pantothenic acid. Chemically it is a triethyl ester, described by chemists as triethyl 2-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)aminoethane-1,1,1-tricarboxylate. Converting natural pantothenic acid into this ester form makes the molecule more stable, less prone to breaking down in water and better at slipping through the skin’s surface.

The ingredient was first explored in the late 20th century when formulators searched for vitamin B5 options that would resist oxidation and deliver longer-lasting softness. By adding ethyl groups, researchers created a version that survives the high temperatures and varied pH ranges common in modern cosmetics. It quickly found a place in European skin care, then expanded worldwide as manufacturers looked for reliable conditioning agents.

Production begins with pharmaceutical-grade pantothenic acid sourced from fermentation of plant sugars. The acid is reacted with ethanol in the presence of a catalyst, forming the triethyl ester. Careful purification removes solvents and by-products, leaving a clear to pale yellow liquid or powder ready for formulation.

You will most often see Ethyl Dicarboethoxy Pantothenate in leave-on products such as daily moisturizers, anti-aging creams, hydrating serums and sheet masks. Its ability to cling to the skin without feeling greasy also makes it popular in primers, BB creams and after-sun gels.

Ethyl Dicarboethoxy Pantothenate’s Cosmetic Benefits/Uses

In skin care formulas Ethyl Dicarboethoxy Pantothenate serves a single yet valuable role.

As a skin conditioning ingredient it attracts and holds moisture, helping the outer layer stay soft smooth and flexible. Regular use can reduce the look of flakiness and fine lines while giving skin a plump healthy appearance. It also supports the skin barrier, which in turn can make the complexion feel calmer and more resilient.

Who Can Use Ethyl Dicarboethoxy Pantothenate

This B5 derivative is gentle enough for nearly every skin type. Dry and mature complexions appreciate the moisture-binding action while normal and combination skin enjoy a lightweight silky feel. Oily or acne-prone users can usually apply it without worrying about extra shine because the molecule is non-oily and has a very low tendency to clog pores. Sensitive skin also tends to tolerate it well since it lacks fragrance and common irritants.

Ethyl Dicarboethoxy Pantothenate is produced from plant-sourced sugars and ethanol then processed in a laboratory so it contains no animal-derived material. For that reason products that list this ingredient alone are generally suitable for vegans and vegetarians, although it is still wise to check the full formula for hidden animal by-products such as beeswax or lanolin.

The compound does not appear on any pregnancy or breastfeeding avoidance lists and absorption through intact skin is minimal. Still this information is not medical advice; anyone who is pregnant or nursing should confirm the safety of their entire skincare routine with a qualified healthcare provider.

The ingredient does not increase photosensitivity so there is no extra sunburn risk beyond everyday UV exposure. It also plays nicely with most actives including retinoids and exfoliating acids thanks to its stable nature across a wide pH range.

Potential Side Effects/Adverse Reactions

Responses to topical Ethyl Dicarboethoxy Pantothenate differ from person to person. The points below cover potential reactions only and most users will not experience them when using a well-formulated product.

  • Mild redness or warmth
  • Temporary stinging on freshly exfoliated or broken skin
  • Allergic contact dermatitis presenting as itching or rash in very rare cases
  • Isolated acne flare if the surrounding formula contains heavy occlusives
  • Swelling or hives in individuals with a specific sensitivity to vitamin B5 derivatives

If any of these reactions occur stop using the product immediately and consult a healthcare professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 out of 5. Ethyl Dicarboethoxy Pantothenate is a lightweight vitamin B5 ester that absorbs quickly and does not leave an oily film, so it has almost no tendency to block pores. For that reason it is generally safe for skin that breaks out easily. As always the full formula matters; rich butters, heavy silicones or waxes paired with this ingredient could still cause congestion in some users.

Summary

Ethyl Dicarboethoxy Pantothenate is a stable vitamin B5 derivative that conditions skin by drawing in water and binding it to the surface. This added moisture softens rough patches, smooths fine lines and helps reinforce the natural barrier so skin feels calm and supple.

While not as famous as niacinamide or hyaluronic acid, it shows up in a steady stream of moisturizers, serums and primers because formulators like its ease of use and reliable performance. Consumers who discover it often stick with it for the silky feel it gives without heaviness.

Overall safety is high with very low rates of irritation or clogged pores. Still every skin is different so it is smart to perform a small patch test when trying any new product that contains this ingredient.

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