Ethyl Nitrotrifluoromethylphenyl Citramalamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Ethyl Nitrotrifluoromethylphenyl Citramalamide?

Ethyl Nitrotrifluoromethylphenyl Citramalamide is a lab-crafted ester derived from butanoic acid that has been modified with a trifluoromethyl group and a nitro group. These small tweaks give the molecule stability and help it interact with excess skin oil. The ingredient does not occur in nature; it was developed in the early 2000s when formulators were searching for gentler ways to manage shine without the drying effect of alcohol-heavy products. Production starts with plant-based butanoic acid. Chemists then run a series of controlled reactions, adding the nitrotrifluoromethylphenyl segment before finishing with an ethyl esterification step. The result is a lightweight, oil-compatible powder that disperses easily in water or silicone bases.

You will most often spot Ethyl Nitrotrifluoromethylphenyl Citramalamide in oil-control masks, mattifying primers, daily moisturizers for combination skin, lightweight sunscreens, leave-on spot treatments and even in setting sprays that promise a long-lasting matte finish.

Ethyl Nitrotrifluoromethylphenyl Citramalamide’s Cosmetic Benefits/Uses

This ingredient is prized for one clear job: keeping unwanted shine in check.

As an anti-sebum agent, Ethyl Nitrotrifluoromethylphenyl Citramalamide helps absorb or bind excess sebum on the skin’s surface. In a formula it can reduce mid-day oil breakthrough, extend makeup wear time and give the complexion a smoother, matte look without stripping natural moisture.

Who Can Use Ethyl Nitrotrifluoromethylphenyl Citramalamide

This ingredient is best suited to oily or combination skin because it targets excess sebum. Normal skin can also benefit in humid weather or when extra shine control is desired. Very dry or mature skin may find it unnecessary and could notice a tighter feel if used too often, so hydrating steps should accompany it. Sensitive skin usually tolerates the molecule well thanks to its low potential for penetration, although formulas that pair it with high levels of alcohol or fragrance could still trigger irritation.

Ethyl Nitrotrifluoromethylphenyl Citramalamide is produced from plant sourced butanoic acid and synthesized entirely in the lab, so it contains no animal derived materials. That makes it suitable for vegetarians and vegans as long as the finished product has not been tested on animals in a way that conflicts with personal ethics.

No published data suggest that the ingredient poses specific risks for pregnant or breastfeeding women when used topically in cosmetics. This is not medical advice and anyone who is pregnant or nursing should discuss any skincare product with a qualified healthcare provider to be safe.

The compound does not absorb UV light and is not known to cause photosensitivity. Normal daily sun protection is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Individual responses to Ethyl Nitrotrifluoromethylphenyl Citramalamide can vary. The points below outline potential side effects that are considered uncommon when the ingredient is used correctly in a well formulated product.

  • Mild skin dryness
  • Temporary tightness or a matte residue that some users find uncomfortable
  • Redness or slight stinging on very sensitive or compromised skin
  • Contact dermatitis in those with a specific allergy to nitro aromatic compounds
  • Increased flaking if combined with strong exfoliants or acne treatments without adequate moisturization

If irritation or any other negative reaction occurs stop use immediately and consult a dermatologist or healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Ethyl Nitrotrifluoromethylphenyl Citramalamide is a lightweight, non-oily powder that sits on the surface of skin and binds excess sebum rather than adding to it. Its large molecular size and lack of fatty acid chains make it unlikely to block pores, hence the low rating of 1. This means the ingredient is generally suitable for people who are prone to acne or frequent breakouts. In rare cases buildup can occur if the product base is heavy with waxes or if it is not properly removed at night.

Summary

Ethyl Nitrotrifluoromethylphenyl Citramalamide is an anti-sebum agent that reduces shine, prolongs makeup wear and gives skin a soft matte finish by absorbing excess oil at the surface. It does this without stripping moisture because it does not penetrate deeply or dissolve the natural lipid barrier.

The molecule is still somewhat niche, found mainly in targeted oil-control products rather than across mainstream lines, but its gentle mattifying effect is gaining attention as consumers look for alternatives to drying alcohol formulas.

Current data show the ingredient is low risk for irritation, non-sensitizing and vegan friendly. As with any new skincare ingredient it is wise to patch test a product first to make sure your individual skin agrees with the formula.

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