Ethylhexanamide Serinol: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Ethylhexanamide Serinol?

Ethylhexanamide Serinol is a lab made ingredient created by joining serinol, a sugar related molecule, with a fatty acid known as ethylhexanoic acid. The result is a lightweight, oil like substance that mixes the water loving side of serinol with the skin softening side of the fatty acid. This balanced structure lets it sink into skin without leaving a heavy or greasy feel.

The compound first showed up in cosmetic labs in the early 2000s when formulators were looking for alternatives to silicone based emollients. Chemists found that linking serinol to ethylhexanoic acid produced a silky ester that could condition skin while keeping formulas stable. Since then it has appeared in a range of leave on and rinse off products.

Manufacturing starts with plant derived serinol, often sourced from corn or sugar beets. The serinol reacts with activated ethylhexanoic acid in a controlled process called amidation. After purification the clear liquid is ready for use.

You will most often spot Ethylhexanamide Serinol in lightweight moisturizers, day creams, sheet masks, cleansing oils, micellar waters, makeup removers, anti aging serums and sunscreens where it helps solubilize UV filters.

Ethylhexanamide Serinol’s Cosmetic Benefits/Uses

Below are the main roles this multitasking ingredient plays in skin care formulas

  • Skin conditioning – leaves skin feeling soft and smooth by reinforcing the outer layer and reducing moisture loss
  • Emollient – fills in tiny gaps between skin cells creating a silky finish that improves spreadability of creams and lotions
  • Skin protecting – forms a light barrier that shields against everyday pollutants and irritants
  • Cleansing – helps break down makeup, sunscreen and excess oil so they can be rinsed away without stripping skin
  • Emulsifying – keeps water and oil ingredients blended, preventing separation and extending product shelf life

Who Can Use Ethylhexanamide Serinol

Thanks to its light texture and low likelihood of clogging pores, Ethylhexanamide Serinol suits normal, dry, combination and oily skin. Those with very sensitive or compromised skin can usually tolerate it but should be aware that any new ingredient could still cause irritation if the barrier is already weakened.

The compound is non animal derived. Serinol is sourced from plants like corn or sugar beet and the fatty acid comes from synthetic or vegetable origins, so finished products that do not include other animal ingredients remain suitable for vegans and vegetarians.

No data suggests the ingredient crosses the skin in amounts that pose a risk during pregnancy or breastfeeding. This is not medical advice and anyone who is pregnant or nursing should review all skincare products with a qualified healthcare provider to stay on the safe side.

Ethylhexanamide Serinol does not increase photosensitivity, meaning it will not make skin more prone to sunburn. Standard daytime sun protection habits still apply when using any skincare routine.

Potential Side Effects/Adverse Reactions

Responses to topical Ethylhexanamide Serinol differ from person to person. The effects below are possible but uncommon when the ingredient is used correctly and formulated within recommended concentrations.

  • Transient stinging: a brief prickling sensation right after application
  • Mild redness: temporary flushing especially on very sensitive skin
  • Contact dermatitis: rare development of itching or small bumps in those allergic to fatty amides
  • Eye irritation: watery or burning eyes if the product migrates too close to the lash line

If irritation, swelling or any persistent discomfort occurs stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1/5

This low score reflects the ingredient’s lightweight amide-ester structure which absorbs quickly instead of pooling in pores. Its balanced water-friendly and oil-friendly sides let it rinse away easily and it is usually used in modest amounts, further reducing any chance of buildup.

With such a mild profile it is generally considered safe for skin prone to acne or frequent breakouts.

It contains no heavy waxes or high-molecular fatty alcohols and has not been flagged for aggravating fungal acne, making it a low-risk choice in most formulations.

Summary

Ethylhexanamide Serinol acts as a skin conditioner, emollient, protector, cleanser and emulsifier by sliding between skin cells to smooth texture, forming a light breathable barrier that slows water loss, dissolving oils and makeup for easy removal and keeping water and oil phases blended for product stability.

While it rarely takes the spotlight it shows up in a steady range of moisturisers, cleansers and sunscreens where chemists value its silky feel and formula-friendly nature.

Overall safety data are reassuring with low rates of irritation or allergy. Still, skin can be unpredictable so patch testing any new product containing Ethylhexanamide Serinol is a smart precaution.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search