What Is Ferric Hexapeptide-35?
Ferric Hexapeptide-35 is a blend of a short chain of six amino acids, called Hexapeptide-35, with iron in its ferric (Fe3+) form. The peptide portion offers skin friendly building blocks while the iron helps stabilize the complex and supports its activity on the skin. This ingredient was born from research into bio-active peptides that could deliver refreshed, conditioned skin without heavy oils or waxes. As formulators experimented with different metal–peptide combinations they found that pairing Hexapeptide-35 with ferric iron produced a stable material that spread well and left skin feeling soft. Commercial production starts by synthesizing the peptide in a lab through standard amino acid coupling methods. The finished peptide is then blended with a purified ferric salt under controlled pH and temperature, allowing the two to bond into the final complex before being dried into a fine powder for easy use in creams and serums. Today you will most often see Ferric Hexapeptide-35 in leave-on products such as anti-aging serums, lightweight moisturizers, sheet masks and eye treatments where it can sit on the skin long enough to deliver its conditioning benefits.
Ferric Hexapeptide-35’s Cosmetic Benefits/Uses
When formulators add Ferric Hexapeptide-35 to a product its main role is skin conditioning. This means it helps the surface of the skin feel smoother, softer and more supple. By supporting the skin’s natural water balance and refining texture it can give a healthier look and a pleasant “silky afterfeel” that users often notice right after application.
Who Can Use Ferric Hexapeptide-35
Ferric Hexapeptide-35 is generally friendly to all major skin types, including dry, normal and oily skin. Its lightweight nature makes it comfortable for combination and acne-prone complexions, as it conditions without adding heavy oils. Sensitive skin usually tolerates the peptide complex well, yet anyone with a known allergy to peptides or iron derivatives should approach with caution.
The ingredient is synthesized in a laboratory without animal-derived materials, so it is suitable for both vegans and vegetarians. No animal testing is required for the ingredient itself in most regions that follow modern cosmetic regulations, though final product policies can vary by brand.
Current safety data show no specific concerns for topical use during pregnancy or breastfeeding. However this is not medical advice and pregnant or nursing users should always review their full skincare routine with a qualified healthcare professional.
Ferric Hexapeptide-35 does not make skin more sensitive to sunlight, so it is considered non-photosensitizing. Daily sunscreen remains a smart habit for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Ferric Hexapeptide-35 can differ from person to person. The points below outline potential side effects, yet most people will not experience them when the ingredient is used correctly in a well-formulated product.
- Mild redness or irritation in very sensitive individuals, usually short-lived
- Itching or tingling if the formula contains other active ingredients that heighten skin reactivity
- Allergic contact dermatitis in rare cases of peptide or metal allergy
- Stinging around the eyes if the product is applied too close to the lash line
If any discomfort or unusual reaction occurs stop using the product and consult a healthcare professional
Comedogenic Rating
Rating: 0/5
Ferric Hexapeptide-35 is a small, water-soluble peptide complex that contains no heavy oils, waxes or fatty acids known to clog pores. Because it dissolves readily in water-based formulas and leaves little to no residue on the skin it earns the lowest possible comedogenic score.
This makes the ingredient generally suitable for acne-prone or breakout-prone skin. Only the overall product vehicle (for example if it is paired with rich plant butters) would change that assessment, not the peptide itself.
One extra point to note is that peptides can sometimes be delivered in silicone gels or emulsions. While most silicones are also low on the comedogenic scale, users who react poorly to certain carriers should check the full ingredient list.
Summary
Ferric Hexapeptide-35 is a lab-crafted complex that conditions skin by supplying amino acid building blocks and supporting surface hydration, leaving skin softer and smoother. Its iron component helps stabilize the peptide so it can perform consistently in leave-on products.
Although not yet a household name it is gaining quiet popularity among formulators looking for lightweight skin conditioners that avoid heavy emollients. You will mostly spot it in modern serums, eye gels and sheet masks aimed at improving texture and bounce.
Current data show it to be a very safe topical ingredient with low irritation potential and no links to photosensitivity. Still, when trying any new product it is wise to patch test first to be sure your skin agrees.