What Is Galloyl Sh-Pentapeptide-5?
Galloyl Sh-Pentapeptide-5 is a hybrid molecule formed when gallic acid, a plant-derived antioxidant commonly found in oak galls and tea leaves, reacts with Sh-Pentapeptide-5, a lab-crafted chain of five amino acids. By linking the peptide to gallic acid, chemists create a compound that blends the firming signal of a peptide with the protective power of a polyphenol. The ingredient emerged in the late 2010s as brands searched for multitasking actives that could smooth skin while defending it against daily stress. Production involves dissolving the peptide in water, introducing activated gallic acid and allowing them to bond under controlled pH and temperature before the mixture is purified, dried and milled into a fine powder. Formulators then blend this powder into water-based phases of products such as anti-aging serums, day and night creams, eye contour gels, sheet masks and general moisturizers where its small size lets it absorb easily.
Galloyl Sh-Pentapeptide-5’s Cosmetic Benefits/Uses
This ingredient is valued for one primary action in topical care.
Skin conditioning: Galloyl Sh-Pentapeptide-5 helps the skin feel softer, look smoother and maintain healthy moisture levels. The peptide fragment encourages a firmer appearance while the gallic acid portion offers antioxidant support, together promoting a fresh, supple complexion.
Who Can Use Galloyl Sh-Pentapeptide-5
Galloyl Sh-Pentapeptide-5 is generally suitable for all skin types including dry, normal, combination, oily and sensitive skin thanks to its lightweight texture and soothing antioxidant profile. Sensitive users often tolerate it well because it is fragrance free and has a low likelihood of stinging, although extremely reactive skin may prefer a lower concentration at first.
The molecule is made by coupling a lab-synthesized peptide with plant-derived gallic acid, so it contains no animal by-products. That makes it appropriate for vegetarians and vegans.
Current data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically at typical cosmetic levels. This is not medical advice, and anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare products.
The ingredient does not increase photosensitivity, so it can be used in morning or evening formulas without raising sunburn risk. Normal daytime SPF protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Galloyl Sh-Pentapeptide-5 vary between individuals. The points below list potential reactions, though most people will not experience them when the ingredient is formulated and used correctly.
- Mild redness or irritation especially on very sensitive skin
- Temporary stinging or tingling immediately after application
- Dry or tight feeling if paired with strong exfoliants or alcohol-heavy products
- Allergic contact dermatitis in rare cases for those sensitive to peptides or polyphenols
Discontinue use and consult a healthcare professional if any of these reactions occur or persist.
Comedogenic Rating
Galloyl Sh-Pentapeptide-5 scores a 0 – 1 on the comedogenic scale. It is water soluble, lightweight and contains no heavy oils or waxes, so it is highly unlikely to clog pores. This makes it suitable for acne-prone skin. Only the other ingredients in a finished formula are likely to influence pore-clogging potential, not the peptide itself.
Summary
Galloyl Sh-Pentapeptide-5 conditions skin by combining a firming pentapeptide with antioxidant gallic acid. Together they help skin stay hydrated, feel smoother and better resist environmental stress. The ingredient is still niche but is slowly gaining attention in modern serums, creams and eye treatments thanks to this multitasking profile.
Available safety data shows it is gentle, non-comedogenic and vegan friendly with no known links to photosensitivity. Even so, it is wise to run a quick patch test when you try any new product that features this peptide to confirm personal tolerance.