Glycereth-6 Trioleate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Glycereth-6 Trioleate?

Glycereth-6 Trioleate is a lab-made ester created by linking glycerin that has been reacted with six units of ethylene oxide to three molecules of oleic acid, the fatty acid best known for its presence in olive oil. The result is an oil-like liquid that blends the water-loving nature of polyethylene glycol with the skin-softening feel of natural lipids. First explored by chemists looking for gentler alternatives to mineral oils in the late twentieth century, it quickly found favor in skin care labs for its ability to moisturize without heaviness.

Manufacturing begins with plant-derived glycerin that is ethoxylated to introduce the six ethylene oxide units, boosting water solubility. This intermediate is then esterified with oleic acid sourced from vegetable oils such as sunflower or canola. The controlled reaction yields a stable triester that remains fluid at room temperature and carries a faint fatty aroma.

Because it bridges oil and water, Glycereth-6 Trioleate slips easily into both water-based and anhydrous products. You will most often spot it in face and body moisturizers, hydrating masks, after-sun lotions, lightweight anti-aging creams and cleansing balms where it helps dissolve makeup while leaving skin supple.

Glycereth-6 Trioleate’s Cosmetic Benefits/Uses

This ingredient earns its place in formulas by enhancing skin feel and helping other ingredients work more smoothly.

  • Skin conditioning: Forms a soft flexible film on the surface that traps moisture, leaving skin feeling smooth and refreshed rather than greasy
  • Emollient: Fills in microscopic cracks in the skin’s surface to improve softness and flexibility which can reduce the appearance of dry flaky patches

Who Can Use Glycereth-6 Trioleate

This silky ester is generally well tolerated by most skin types, including normal, dry, combination and even oily skin since it absorbs without a heavy residue. Those with very acne-prone skin should monitor how their skin responds because any rich emollient can potentially clog pores for some individuals.

It is produced from vegetable-derived glycerin and plant oils, with no animal by-products, so it fits vegan and vegetarian lifestyles when sourced from a cruelty-free brand.

Current safety data show no special warnings for topical use during pregnancy or while breastfeeding. This is not medical advice; anyone who is pregnant or nursing should check with a healthcare provider before adding new skincare products.

Glycereth-6 Trioleate does not make skin more sensitive to sunlight, so it can be used morning or night. As always, daily sunscreen remains important for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient differ from person to person. The points below outline potential but uncommon reactions when Glycereth-6 Trioleate is applied to skin. In a well-formulated product most users will not notice any of these issues.

  • Mild irritation such as redness or stinging, especially on very sensitive skin
  • Allergic contact dermatitis in individuals allergic to polyethylene glycol derivatives or oleic acid
  • Temporary breakouts or pore congestion in those highly prone to acne
  • Rare rash or itching linked to fragrance or other co-ingredients rather than the ester itself

If irritation or any adverse change occurs stop using the product and consult a qualified healthcare professional.

Comedogenic Rating

Rating: 2 out of 5

Although the molecule carries three oleic acid chains, their attachment to a polyethylene-glycolated glycerin backbone increases water affinity and reduces the chance of the ester lodging in pores. Limited lab data and anecdotal user feedback place it in the low to moderate range for clogging potential. Most skin types tolerate it well yet those who break out easily could notice occasional congestion if the surrounding formula is very rich. The overall product blend and concentration ultimately dictate whether it feels light or heavy on the skin.

Summary

Glycereth-6 Trioleate conditions skin and acts as an emollient by combining a water-friendly PEG-glycerin head with three smoothing oleic acid tails. This structure lets it attract a hint of hydration while laying down a thin flexible layer that softens rough patches and enhances glide in creams, balms and lotions.

It remains more of a behind-the-scenes helper than a headline ingredient, appearing in select moisturizers, cleansing balms and after sun treats where formulators value its light feel and stability.

Safety evaluations mark it as low risk with only rare irritation or allergy reports. Still, trying a small patch before full use is a smart practice when introducing any new cosmetic product.

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