Glyceryl Diisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Glyceryl Diisostearate?

Glyceryl Diisostearate is a plant or animal-derived glycerin molecule that has been esterified with two molecules of isostearic acid, a branched form of stearic acid. The result is a creamy, wax-like substance that is oil soluble yet disperses nicely when blended with water-based ingredients in a formula. First explored in the mid-20th century as chemists searched for gentler alternatives to mineral oil derivatives, it quickly found a place in color cosmetics and skin care for its soft feel and stabilizing power.

Commercial production starts with sustainable vegetable oils such as soybean or palm. The oils are split to obtain glycerol and fatty acids. Through controlled heating and the use of an acid or enzymatic catalyst, two isostearic acid molecules bond with one glycerol molecule. The purified ester is then melted, filtered and milled into pastilles or flakes ready for cosmetic labs.

You will most often spot Glyceryl Diisostearate in creamy foundations, lipsticks, masks, rich moisturizers, body butters, sunscreens and anti-aging formulas where a smooth glide and a bit of opacity are welcome.

Glyceryl Diisostearate’s Cosmetic Benefits/Uses

Formulators reach for Glyceryl Diisostearate because it multitasks beautifully

  • Opacifying: Adds a soft-focus veil to lotions and makeup, helping blur minor skin imperfections and giving products a luxurious, non-transparent appearance
  • Emollient: Leaves a light protective layer on the skin that reduces water loss, smooths rough patches and imparts a silky, non-greasy after-feel
  • Emulsifying: Helps oil and water mix evenly, improving texture stability and preventing separation so the product feels consistent from the first use to the last

Who Can Use Glyceryl Diisostearate

Most skin types tolerate Glyceryl Diisostearate well. Its light occlusive film helps dry, normal and mature skin hold on to moisture while its non greasy feel keeps combination skin comfortable. Very oily or congestion-prone skin might prefer lighter textures since any rich emollient can sometimes feel heavy or contribute to a shiny finish.

The ingredient itself can be produced from either plant oils or animal fats. Brands that rely on plant sources usually mention it on the label or in their marketing, making those versions suitable for vegans and vegetarians. If the origin is not specified, anyone following a strict vegan lifestyle may want to confirm the supply chain with the company.

Glyceryl Diisostearate is considered safe for use during pregnancy and while breastfeeding because it stays on the surface of the skin and is not known to penetrate deeply. This is not medical advice and pregnant or nursing women should double-check any skincare product with their doctor just to be safe.

It does not increase photosensitivity, so there is no added risk of sunburn when using products that contain it. As always, daily sunscreen is still a good idea.

Potential Side Effects/Adverse Reactions

Reactions to Glyceryl Diisostearate differ from person to person. The points below list potential issues and most users will not experience them when the ingredient is used correctly in a well-formulated product.

  • Mild skin irritation or redness in very sensitive individuals
  • Allergic contact dermatitis for those specifically allergic to isostearic acid derivatives
  • Clogged pores or breakouts in skin already prone to acne if used in a heavy formula
  • Temporary eye irritation if the product accidentally gets into the eyes

If you notice any of these effects stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 2/5. Glyceryl Diisostearate is a moderately lightweight ester of a branched fatty acid, so it sits on the skin without sinking deeply into pores yet still forms a soft film. Most dermatology references group it with other glyceryl esters that register around the low to mid range for pore clogging potential. It is therefore unlikely to trigger breakouts on its own but could add to the overall occlusive load in a very rich formulation.

Suitable for acne-prone or congestion-prone skin if used in a well balanced product with a lighter texture. Those dealing with stubborn or cystic acne may prefer to keep total fatty ester content low.

Keep in mind that comedogenicity ratings are guides based on isolated testing. The final product’s full recipe, how much of the ingredient is used and personal skin behavior all influence whether pores actually clog.

Summary

Glyceryl Diisostearate acts mainly as an opacifier, emollient and helper emulsifier. Its branched fatty chains scatter light to create a soft focus finish, its glycerol backbone leaves a breathable moisturizing layer and its partial affinity for both oil and water helps stabilize creamy formulas.

While not as famous as hyaluronic acid or shea butter it is a quiet workhorse in foundations, lipsticks and rich lotions where smooth glide and stability matter. Brands like it because it is easy to source from plants and has a pleasant skin feel.

Current safety reviews rate it as low risk with only rare irritation or allergy cases reported. As with any new cosmetic it is smart to patch test first to be sure your skin plays nicely with the full formula.

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