Glycyrrhiza Uralensis Root Prenylflavonoids: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Glycyrrhiza Uralensis Root Prenylflavonoids?

Glycyrrhiza Uralensis Root Prenylflavonoids come from the roots of the licorice plant Glycyrrhiza uralensis, a member of the bean family. Within these roots are special plant compounds called prenylflavonoids, which are flavonoids that carry an extra carbon side chain known as a prenyl group. This small structural twist makes them more oil-loving than regular flavonoids so they mix well with the skin’s natural oils.

Licorice root has been prized in East Asian beauty rituals for centuries, mainly for its soothing and brightening qualities. Modern extraction methods involve drying the roots, grinding them into a powder then using food-grade solvents to pull out the prenylflavonoids. After filtration and purification, the concentrate is standardized for consistent strength before it goes into skin care formulas.

You will usually spot Glycyrrhiza Uralensis Root Prenylflavonoids in products aimed at calming or revitalizing the skin. They appear in lightweight serums, daily moisturizers, sheet masks, night creams and targeted spot treatments where a gentle conditioning boost is desired.

Glycyrrhiza Uralensis Root Prenylflavonoids’s Cosmetic Benefits/Uses

This ingredient is mainly valued for one key function in cosmetics: skin conditioning. It helps soften and smooth the surface, supports a comfortable feel after application and can improve the overall appearance of dull or stressed skin.

Who Can Use Glycyrrhiza Uralensis Root Prenylflavonoids

This ingredient is generally well tolerated by all skin types including dry, oily, combination and sensitive skin because it is lightweight and non-clogging. Those with an existing allergy to licorice or other members of the bean family should avoid it to prevent irritation.

Since it is extracted solely from plant roots and no animal derivatives or by-products are involved in the harvesting or processing steps, Glycyrrhiza Uralensis Root Prenylflavonoids are suitable for both vegans and vegetarians.

Topical use during pregnancy or while breastfeeding is considered low risk due to the tiny amounts absorbed into the bloodstream, yet studies in these groups are limited. This is not medical advice so anyone who is pregnant or nursing should show the full ingredient list of any product to a qualified healthcare provider before adding it to a routine, just to be on the safe side.

The ingredient is not known to trigger photosensitivity. Routine daytime sun protection is still recommended because UV exposure remains the biggest driver of premature skin aging.

Potential Side Effects/Adverse Reactions

Reactions to topical Glycyrrhiza Uralensis Root Prenylflavonoids vary from person to person. The points below list potential side effects only and most users will not experience them when the ingredient is formulated properly.

Allergic contact dermatitis – redness, itching or a rash in those sensitive to licorice or related plants

Localized stinging or burning – usually mild and short-lived, more likely if applied to compromised skin

Skin dryness or flaking – uncommon but possible if the overall formula is not sufficiently hydrating

If any of these effects occur discontinue use and seek advice from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1 out of 5

The prenylflavonoids come from a root extract that is mostly lightweight and not oily. While the added prenyl group makes them a bit more oil friendly than standard flavonoids, the levels used in skin care are small so they rarely block pores. This makes the ingredient generally suitable for people who are prone to acne or breakouts.

As with any component, the final formula matters. If the product also contains heavy oils or waxes the overall pore-clogging risk may rise, but the prenylflavonoids themselves stay low on the scale.

Summary

Glycyrrhiza Uralensis Root Prenylflavonoids mainly condition the skin, helping it feel softer and look more even. Their mild soothing and brightening touch comes from the natural antioxidant power of the prenylflavonoids and their ability to sit well within the skin’s own oils.

The ingredient is still a niche pick, showing up more in targeted Asian beauty lines and select indie brands than in mass market products, yet interest is growing as formulators search for gentle plant based boosters.

Overall safety is high with only rare reports of irritation in people who are sensitive to licorice or legumes. As with any new product, do a quick patch test first so you can spot an issue before applying it to your whole face.

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