What Is Heptapeptide-37?
Heptapeptide-37 is a lab-made chain of seven amino acids built mainly from cysteine, glutamine, glycine and proline. Because it is synthesized rather than taken from animals or plants, it offers a high level of purity and consistency from batch to batch.
The cosmetic world began exploring short peptides in the late 1990s for their skin-friendly properties. As research on signal peptides expanded, formulators identified Heptapeptide-37 for its noticeable skin conditioning abilities, leading to its steady inclusion in beauty products over the last decade.
Production starts with solid-phase peptide synthesis, a step-by-step method where each amino acid is added in a controlled sequence. Once the seven-unit chain is complete the peptide is cleaved from its resin base, purified through filtration and chromatography, then dried into a fine powder ready for use.
You will most often spot Heptapeptide-37 in leave-on products like serums, lightweight lotions, anti-aging creams, under-eye treatments and sheet masks where its conditioning effect can remain on the skin for hours.
Heptapeptide-37’s Cosmetic Benefits/Uses
Formulators turn to this peptide for one key reason: its proven ability to condition skin.
As a skin-conditioning agent Heptapeptide-37 helps the surface feel softer and more supple while supporting a healthier moisture balance. Regular use may improve the appearance of fine texture and create a smoother canvas for makeup or sunscreen layered on top.
Who Can Use Heptapeptide-37
This peptide is considered suitable for all skin types, from dry to oily, because it is lightweight, water soluble and non occlusive. Sensitive skin tends to tolerate it as it is free from fragrance, dyes and common sensitizers. People with a known allergy to any of its amino acid building blocks should avoid it.
Heptapeptide-37 is produced entirely in the lab without animal byproducts, making it appropriate for vegans and vegetarians.
No research has flagged topical Heptapeptide-37 as unsafe during pregnancy or breastfeeding when used in typical cosmetic concentrations. Still this article is not medical advice. Expectant or nursing mothers should discuss any skincare routine with their healthcare provider for individual guidance.
The ingredient does not cause photosensitivity so it can be applied day or night. Regular use of sunscreen in the daytime is still recommended to guard against everyday UV damage.
Potential Side Effects/Adverse Reactions
Reactions vary between individuals. The following are potential side effects yet they are uncommon when the peptide is used in a well formulated product.
- Temporary redness
- Mild itching or tingling after application
- Rare allergic contact dermatitis in peptide sensitive users
- Eye irritation if the product is accidentally introduced into the eyes
If any adverse reaction occurs stop use and consult a medical professional if symptoms persist.
Comedogenic Rating
Rating: 0 / 5 (non comedogenic)
Heptapeptide-37 is water soluble and contains no heavy oils or waxes that can block pores, so it earns the lowest possible score. Its small peptide structure rinses cleanly from the skin and does not create a film that traps sebum or dead cells.
Because of this, the ingredient is generally safe for people who are prone to acne or breakouts.
The only caveat is the overall formula: if the peptide sits in a cream rich in butters or silicones, those other ingredients could raise the clogging potential.
Summary
Heptapeptide-37 is a lab made chain of seven amino acids used mainly to condition skin. It helps the surface feel smoother and more hydrated by supporting the skin’s natural moisture balance and softening texture.
While it is not yet a household name like retinol or vitamin C, the peptide has a steady following in niche serums and eye creams and its presence is growing as brands look for gentle active ingredients.
Safety data show a very low risk of irritation, allergic reaction or clogged pores when the peptide is used at normal cosmetic levels. Even so, it is smart to patch test any new product to make sure your skin agrees with the complete formula.