What Is Hexacarboxymethyl Lysinyl Lysinamide?
Hexacarboxymethyl Lysinyl Lysinamide is a lab-made version of a natural amino acid. Chemists attach carboxymethyl groups to the amino acid lysine to give it strong water-binding power. The finished ingredient looks like a fine white powder that dissolves easily in water. It first appeared in skincare research in the early 2000s when formulators were searching for alternatives to glycerin that could attract and hold more moisture. Production starts with pharmaceutical-grade lysine that is reacted with chloroacetic acid under controlled pH and temperature. The mixture is purified, dried then milled to a consistent particle size for use in cosmetics.
You are most likely to see Hexacarboxymethyl Lysinyl Lysinamide in leave-on products where long-lasting hydration is a priority. Typical placements include lightweight moisturizers, anti-aging serums, overnight masks, refreshing face mists and hydrating primers. Some brands add it to sheet mask essences or hand creams that promise a “water lock” effect.
Hexacarboxymethyl Lysinyl Lysinamide’s Cosmetic Benefits/Uses
Its main job in a formula is to act as a humectant, meaning it pulls moisture from the surrounding air and from deeper skin layers toward the surface. By bringing extra water to the outer skin, it helps skin feel softer, look plumper and maintain a healthy barrier. Formulators appreciate that it can deliver this boost without a sticky afterfeel, so products stay comfortable and lightweight.
Who Can Use Hexacarboxymethyl Lysinyl Lysinamide
This humectant is gentle enough for most skin types. Dry and dehydrated skin benefit most from the extra water it attracts, while oily skin usually appreciates its weightless feel that adds moisture without grease. Combination and mature skin types can also gain plumping and smoothing effects. The molecule has a low irritation profile, so even sensitive skin generally tolerates it, though formulas with very high concentrations may tingle on freshly exfoliated or compromised skin.
Hexacarboxymethyl Lysinyl Lysinamide is created from synthetic or plant sourced lysine and does not rely on animal by-products, making it appropriate for vegans and vegetarians.
Current safety data shows no specific risks for pregnant or breastfeeding women when the ingredient is used topically at the levels found in cosmetics. This is not medical advice and anyone who is pregnant or nursing should confirm product choices with a healthcare professional to be sure.
The ingredient is not known to cause photosensitivity, so daytime use does not increase the skin’s vulnerability to sunburn. It is water soluble, rinses away easily and does not interfere with most common actives or sunscreen filters.
Potential Side Effects/Adverse Reactions
Individual responses to topical Hexacarboxymethyl Lysinyl Lysinamide can differ. The effects listed below are possible yet uncommon when the ingredient is properly formulated and used as directed.
- Mild redness or warmth in very sensitive skin
- Transient stinging on broken or freshly shaved skin
- Rare allergic contact dermatitis presenting as itching or small bumps
- Tight or sticky afterfeel if layered with many other humectants in low humidity
If any of these reactions occur stop using the product and consult a qualified medical professional.
Comedogenic Rating
Rating: 0/5. Hexacarboxymethyl Lysinyl Lysinamide is completely water soluble, lightweight and non-film forming so it does not trap oil or dead skin that could clog pores. It is therefore considered non-comedogenic and is generally fine for people who struggle with acne or frequent breakouts. Only a very rich or greasy formula surrounding it would change that risk and in that situation the base oils, not this humectant, would be responsible.
Summary
Hexacarboxymethyl Lysinyl Lysinamide is a lab crafted version of lysine that acts mainly as a humectant, drawing water into the upper layers of skin to boost softness and plumpness without a sticky feel. It performs this job thanks to multiple carboxymethyl groups that latch onto water molecules and hold them in place.
While still a niche ingredient compared with classics like glycerin or hyaluronic acid it is gaining quiet popularity among formulators who want strong hydration with a lighter skin finish. Consumers may notice it more often in newer hydrating serums, mists and overnight masks.
Current research and use levels show it to be very safe with a low irritation profile. As with any new skincare ingredient it is smart to patch test a product before full use just to make sure your skin stays happy.