What Is Hexapeptide-37?
Hexapeptide-37 is a lab-made chain of six amino acids built mainly from alanine, proline, serine and glycine. Scientists designed this short peptide to mimic fragments found naturally in skin proteins, with the goal of supporting a healthy moisture balance. First explored in anti-aging research in the early 2000s, it soon found a place in skincare formulas when early studies showed it could leave skin feeling smoother and better hydrated. Production starts with individual amino acids that are linked together in a precise order using solid-phase peptide synthesis, then purified and blended into a water-based solution that fits easily into cosmetic formulas. Today you will spot Hexapeptide-37 in leave-on products such as serums, lightweight moisturizers, sheet masks and eye creams that target dryness or early signs of aging.
Hexapeptide-37’s Cosmetic Benefits/Uses
Its main role on an ingredient list is Skin Conditioning. By helping the outer layer of skin bind and hold water, Hexapeptide-37 can improve softness and flexibility, giving formulas a quick-hydration boost that leaves the surface feeling smooth and refreshed.
Who Can Use Hexapeptide-37
Hexapeptide-37 is generally suitable for all skin types, from dry and mature to oily and acne prone. Its lightweight, water based nature means it will not clog pores or leave a greasy film, making it friendly even for combination and sensitive complexions. At this time there are no known concerns that make it unsuitable for any specific skin type, though ultra reactive skin may want to proceed cautiously whenever a new peptide is introduced.
Because the peptide is synthesized entirely in the lab, it contains no animal derived raw materials. This makes it a vegan and vegetarian friendly option, provided the finished product is certified cruelty free by the brand.
Current data suggests topical Hexapeptide-37 poses a very low risk of systemic absorption, so it is generally considered safe for use during pregnancy and breastfeeding. This is not medical advice and pregnant or nursing individuals should clear all skincare products with their healthcare provider to be safe.
The ingredient does not trigger photosensitivity, so there is no special need to avoid daylight when using it. Standard daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Hexapeptide-37 vary from person to person. The following list covers potential reactions yet most users will not experience any of them when the ingredient is correctly formulated and used as directed.
- Mild redness or flushing shortly after application
- Temporary tingling or stinging sensation
- Itchiness on very sensitive skin
- Contact dermatitis or hives in rare cases of peptide allergy
- Increased irritation when layered with highly acidic exfoliants or strong retinoids
If any of these effects occur discontinue use and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 / 5 — Hexapeptide-37 is a small, water-soluble peptide with no oily or waxy components, so it does not block pores or create the kind of film that can trap sebum. This makes it an excellent choice for people prone to acne or breakouts. The only time it could indirectly contribute to congestion is if the finished product pairs the peptide with rich butters or heavy silicones, so always check the full ingredient list.
Summary
Hexapeptide-37 is a lab-crafted chain of six amino acids that conditions skin by binding water to the outer layers, boosting softness, flexibility and hydration. It is showing up more often in lightweight serums and moisturizers, though it is still less common than buzzier peptides like Matrixyl or Argireline. Overall safety is high: it is non-comedogenic, vegan friendly, pregnancy safe for most users and rarely linked to irritation. Even so, skin can be unpredictable, so do a quick patch test whenever you try a new product containing Hexapeptide-37 just to stay on the safe side.