What Is Horseradish Peroxidase?
Horseradish peroxidase is an enzyme extracted from the roots of the horseradish plant, scientifically known as Cochlearia armoracia L. The enzyme belongs to the peroxidase family and is valued for its ability to speed up certain chemical reactions that involve oxygen. First isolated for laboratory work in the mid-1900s, it eventually found a place in cosmetics when researchers noticed its gentle yet effective skin conditioning properties.
To obtain the ingredient, fresh horseradish roots are cleaned, ground into a pulp and filtered. The liquid extract then goes through purification steps such as precipitation and chromatography to isolate the active enzyme. Finally, the purified horseradish peroxidase is stabilized, dried or solubilized, and blended into cosmetic bases.
You will most often see it in serums, sheet masks, anti-aging creams, soothing gels and specialty treatments aimed at improving overall skin texture.
Horseradish Peroxidase’s Cosmetic Benefits/Uses
Horseradish peroxidase is prized in skin care formulas for one key role.
Skin conditioning: The enzyme helps keep the skin’s surface smooth and soft by supporting a balanced moisture barrier. This can lead to skin that feels hydrated, looks more even and is better able to defend itself against daily stress.
Who Can Use Horseradish Peroxidase
Horseradish peroxidase is generally well tolerated by all major skin types, including dry, oily, combination and mature skin. Those with very sensitive skin or known allergies to horseradish or other plants in the Brassicaceae family should proceed cautiously since even trace botanical residues could trigger irritation.
The enzyme is plant derived, so it aligns with vegan and vegetarian lifestyles as long as the finished formula contains no animal based stabilizers or by-products.
No studies suggest that topical horseradish peroxidase poses a specific risk to women who are pregnant or breastfeeding. Absorption through intact skin is minimal, yet this is not medical advice and anyone expecting or nursing should confirm product choices with a doctor to be safe.
The ingredient does not cause photosensitivity and can be used both day and night without increasing vulnerability to sunburn. It also plays well with most common actives like niacinamide and hyaluronic acid, making it easy to slot into existing routines.
Potential Side Effects/Adverse Reactions
Side effects from topical horseradish peroxidase vary from person to person. The points below cover potential reactions, though they are not expected to be the norm when the ingredient is properly formulated.
- Allergic contact dermatitis: Redness, itching or rash in individuals allergic to horseradish or related plants
- Mild stinging or irritation: Temporary tingling that usually subsides quickly
- Reduced product performance: Enzyme breakdown in unstable formulas leading to little or no visible benefit
- Interaction with peroxide based treatments: Combined use may heighten irritation or diminish efficacy of either product
If you notice any unwanted reaction stop using the product and consult a dermatologist or healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Horseradish peroxidase is a water-soluble enzyme with no oily or waxy components, so it does not sit in pores or form films that might trap dead skin cells. Because it breaks down easily in water and is used at very low concentrations, the likelihood of it clogging pores is essentially nil.
That means the ingredient is generally suitable for people who are prone to acne or frequent breakouts.
Keep in mind that the final product’s overall formula matters. If the enzyme is blended into a rich cream packed with heavier oils, that cream—not the enzyme—could still trigger congestion in very reactive skin.
Summary
Horseradish peroxidase is mainly used for skin conditioning. The enzyme supports a healthy moisture barrier, which in turn helps skin feel smoother, look more even and stay resilient against daily stress. It does this by facilitating mild biochemical reactions at the surface that reinforce the skin’s natural protective layers.
You will not find it on every store shelf. Its use is mostly limited to targeted serums, sheet masks or advanced formulations where brands want a plant-based enzyme to differentiate the product. Despite its fairly low profile, formulators appreciate it for being gentle, vegan friendly and versatile.
Safety data and practical experience show that horseradish peroxidase is low risk for most users, including those with sensitive or acne-prone skin. As with any new skincare ingredient it is wise to perform a quick patch test to ensure personal compatibility.