Hydrolyzed Placental Protein: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Placental Protein?

Hydrolyzed Placental Protein is a blend of amino acids, short chains of proteins called peptides, and larger proteins that come from the placenta of mammals most often sheep. Companies began exploring placental extracts in the 1950s after noticing their rich mix of nutrients and growth factors. Over time scientists learned that breaking the raw placental material into smaller parts through a process called hydrolysis made it safer, more stable and easier for skin and hair to absorb.

To create the ingredient the collected placenta is cleaned then treated with acid, alkaline solution or special enzymes. These steps split the long proteins into a finer mix that dissolves in water and blends well with creams and lotions. After filtering and heat treatments to remove unwanted fats and sugars the final liquid or powder is ready for formulators.

You will spot Hydrolyzed Placental Protein in a wide range of beauty items such as shampoos, rinse out and leave in conditioners, anti frizz serums, sheet masks, anti aging face creams, intensive moisturizers and specialty treatments aimed at dull or damaged skin and hair.

Hydrolyzed Placental Protein’s Cosmetic Benefits/Uses

When added to a formula this ingredient can play several helpful roles

  • Antistatic – helps cut down on static electricity in hair so strands lie smoothly instead of flying away which leaves styles looking sleeker and easier to manage
  • Hair conditioning – coats and penetrates the hair shaft to replace lost moisture and protein giving hair a softer feel more shine and better strength against breakage
  • Skin conditioning – supplies amino acids that attract water and support the skin’s natural barrier leading to improved hydration smoother texture and a more supple appearance

Who Can Use Hydrolyzed Placental Protein

This ingredient generally suits most skin types including dry, normal, combination and mature because its amino acids are lightweight and hydrating. Very sensitive or highly reactive skin may want to proceed cautiously since the protein mix is of animal origin and contains naturally occurring bioactive compounds that could provoke irritation in rare cases. Oily or acne-prone skin usually tolerates it well as it has a low clogging potential and absorbs quickly.

Because it is sourced from animal placenta it is not appropriate for vegans or strict vegetarians who avoid animal-derived ingredients.

Current research shows no specific risks for pregnant or breastfeeding women when the ingredient is applied topically however safety data are limited. This information is not medical advice and anyone who is pregnant or nursing should review any new skincare or haircare product with a qualified healthcare provider first.

Hydrolyzed Placental Protein does not heighten sun sensitivity so it can be used morning or night without increasing the likelihood of sunburn. As with any bioactive extract storage conditions and preservative systems matter so always choose products from reputable brands that follow good manufacturing practices.

Potential Side Effects/Adverse Reactions

Responses to topical Hydrolyzed Placental Protein differ from person to person. The points below outline possible reactions but most people will not experience them when the ingredient is properly formulated and preserved.

  • Allergic reaction or sensitization – redness itching or hives can occur in individuals sensitive to animal proteins
  • Irritation in very sensitive skin – mild stinging or burning may appear especially on compromised or freshly exfoliated skin
  • Contact dermatitis in those with wool or lanolin allergies – the sheep origin can trigger similar immune responses
  • Breakouts in extremely acne-prone users – although rare some may notice blocked pores if the overall formula is heavy or occlusive
  • Odor issues – poorly processed extracts can develop an unpleasant scent that some users find bothersome

If any discomfort swelling or persistent redness develops stop using the product immediately and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 1 / 5 – Hydrolyzed Placental Protein is largely made of water-soluble amino acids and peptides that do not sit heavily on the skin or trap oil, so it has a very low likelihood of clogging pores. Only traces of residual lipids remain after processing which keeps the rating closer to non-comedogenic territory.

Suitable for acne-prone or breakout-prone skin in most cases, provided the rest of the formula is also lightweight and non-greasy.

Because this ingredient comes from animal tissue, slight batch-to-batch variability can occur. Choosing products from reputable brands helps ensure consistent purity that supports the low comedogenic profile.

Summary

Hydrolyzed Placental Protein conditions skin and hair, tames static and supplies moisture-binding amino acids that reinforce the skin barrier and fill in weak spots along the hair shaft. It does this by delivering small, water-loving peptides that penetrate easily and form a flexible film on the surface.

Although not as trendy as plant-based proteins like soy or wheat, it maintains a niche following in premium hair care and anti-aging lines where users appreciate its silky after-feel and strengthening effect.

Topical use is considered low risk for most people with only rare reports of irritation or allergy. As with any new cosmetic ingredient it is wise to patch test before regular use, especially if you have a history of sensitivities.

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