Hydrolyzed Prune Seedcake/Mdi Copolymer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Prune Seedcake/Mdi Copolymer?

Hydrolyzed Prune Seedcake/Mdi Copolymer is a specialty ingredient created from the leftover seedcake that remains after oil is pressed out of prune seeds. The seedcake is first broken down with water to release its proteins and sugars, a process called hydrolysis. These smaller pieces are then reacted with methylene diphenyl diisocyanate, forming a gentle film-forming copolymer that blends plant-based fragments with a synthetic backbone. This hybrid approach started gaining attention in the early 2000s when formulators looked for natural by-products that could improve skin feel while reducing waste from food processing. Production involves collecting prune seed residue, running it through controlled hydrolysis, purifying the hydrolysate, then combining it with MDI under precise temperature and pH to build the final copolymer. The finished material appears as a water-dispersible powder or liquid that is easy to add during the cool-down phase of manufacturing.

You will most often see Hydrolyzed Prune Seedcake/Mdi Copolymer in leave-on products such as daily moisturizers, anti-aging creams, protective day lotions, makeup primers, sheet masks and hydrating serums. It can also be included in rinse-off cleansers and gentle exfoliating treatments where a light protective veil is desired after washing.

Hydrolyzed Prune Seedcake/Mdi Copolymer’s Cosmetic Benefits/Uses

This ingredient is prized for one clear role in skin care.

As a skin-protecting agent, Hydrolyzed Prune Seedcake/Mdi Copolymer forms a thin, flexible film on the surface of the skin that helps lock in moisture, shields against environmental stress and smooths texture so other actives spread more evenly. This protective layer can make the complexion feel softer and look healthier throughout the day while reducing tightness that often follows cleansing or exposure to dry air.

Who Can Use Hydrolyzed Prune Seedcake/Mdi Copolymer

This ingredient is generally well suited to most skin types including normal and dry skin as well as combination or oily complexions because the lightweight film it forms does not feel greasy or heavy.

Those with sensitive or compromised skin can usually tolerate it since the copolymer sits on the surface rather than penetrating deeply, though people with a known allergy to prune or other stone fruits should approach with caution.

The material is derived from plant by-products and a synthetically produced linking agent, so it contains no animal materials. That makes it acceptable for both vegans and vegetarians.

Current safety data do not flag any specific risk for pregnant or breastfeeding women when this ingredient is used in topical cosmetics. This is not medical advice and anyone who is expecting or nursing should review all skincare products with a qualified healthcare professional to be safe.

Hydrolyzed Prune Seedcake/Mdi Copolymer does not make skin more sensitive to sunlight so it is not considered photosensitizing. Standard daily sunscreen use is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Reactions to topical Hydrolyzed Prune Seedcake/Mdi Copolymer differ from person to person. The effects listed below are potential issues that could arise yet they are uncommon when the ingredient is properly formulated and used as directed.

  • Mild skin irritation such as redness or stinging, typically in very sensitive individuals
  • Allergic contact dermatitis in people allergic to prune, other stone fruits or isocyanate derivatives
  • Temp​orary tight feeling if applied in high concentrations without adequate moisturizers underneath
  • Rare clogging or filmy residue on extremely oily skin if layered with heavy occlusives

If any irritation or other negative reaction occurs stop using the product and seek advice from a medical professional or dermatologist.

Comedogenic Rating

Rating: 1 out of 5. Hydrolyzed Prune Seedcake/Mdi Copolymer is primarily a water-dispersible film former rather than an oily emollient, so it does not sink into pores or create a heavy occlusive layer. The light breathable veil it leaves on skin rarely traps sebum or debris, which keeps the likelihood of clogging low. It is therefore considered suitable for people who are prone to acne or frequent breakouts. As with any ingredient, the final product formula matters; pairing this copolymer with thick butters or high-level waxes could raise the overall comedogenic potential of the finished product.

Summary

Hydrolyzed Prune Seedcake/Mdi Copolymer is used in skincare as a skin-protecting agent that forms a thin flexible film to lock in moisture soften texture and guard against daily environmental stress. By combining hydrolyzed prune seed proteins with a synthetic backbone it delivers natural feel with reliable performance.

It remains a niche ingredient, appreciated by formulators looking to upcycle plant by-products but not yet common in mainstream brands. Existing safety data show it to be low risk with minimal irritation potential when used as directed. Patch testing any new product that contains this copolymer is still a smart precaution to confirm personal compatibility.

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