Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment?

Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment is a fermented blend created by feeding coenzyme Q10 (ubiquinone) to two well known microbes, the yeast Saccharomyces and the probiotic Lactobacillus. After fermentation the mixture is hydrolyzed, which breaks the large molecules into smaller fragments that skin can recognize and use. The finished ingredient holds peptides, amino acids, mineral traces and tiny, water-friendly pieces of Q10, giving it both antioxidant and conditioning power.

Fermented ingredients gained attention in the late 1990s thanks to Japanese and Korean skin care, where they were prized for delivering nutrients in a gentler, more bioavailable form. Adding Q10 to the process was the next step for formulators looking to pair the energy boosting reputation of Q10 with the skin friendly profile of fermented actives. Today suppliers produce this ferment in controlled tanks: first they culture Saccharomyces and Lactobacillus with a Q10-rich broth, then filter the liquid, apply gentle enzymes to hydrolyze it and finally refine the solution into a clear, water soluble concentrate ready for cosmetic labs.

You will often spot Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment in lightweight serums, anti aging creams, sheet masks, eye treatments, hydrating lotions and even soothing after-sun gels. It is valued for delivering antioxidant support alongside a smooth skin feel without adding heaviness or oil.

Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment’s Cosmetic Benefits/Uses

This multi-tasking ferment offers several advantages when blended into skin care formulas

  • Reducing: Acts as an antioxidant that helps neutralize free radicals generated by UV light and pollution which can soften the look of lines and dullness
  • Skin Conditioning: Supplies amino acids and peptides that attract moisture and support a supple, comfortable skin surface, leaving it feeling smoother and better hydrated
  • Skin Protecting: Helps reinforce the skin barrier and calm signs of stress so skin is better able to defend itself against everyday environmental aggressors

Who Can Use Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment

This ferment is generally well tolerated by all major skin types including dry, normal, combination, oily and sensitive skin because it is water based and lightweight. Those prone to fungal acne sometimes worry about yeast derived ingredients but the final hydrolyzed material contains no live microbes and has not been shown to feed malassezia so it is usually considered safe in that regard. People with a known allergy to yeast extracts should still approach carefully.

The ingredient is produced from microorganisms rather than animal sources so it is suitable for both vegetarians and vegans.

There are no specific warnings against use during pregnancy or while breastfeeding. That said this is not medical advice and anyone who is pregnant or nursing should show their full routine to a qualified healthcare provider to be on the safe side.

Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment does not make skin more sensitive to sunlight so it is not classed as photosensitizing. Daily sunscreen is still a smart idea for overall skin health.

Potential Side Effects/Adverse Reactions

Reactions to topical Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment vary from person to person. The points below cover potential issues, though most people will not experience them when the ingredient is used correctly in a finished product.

  • Allergic redness or itching: very rare but possible in individuals sensitive to yeast or probiotic extracts
  • Mild stinging on first use: usually transient and linked to the acidic pH of some finished formulas
  • Contact dermatitis: an uncommon inflammatory response that can occur with any cosmetic ingredient if the skin barrier is already compromised
  • Interaction with highly acidic or high alcohol products: layering with strong exfoliating acids or high proof toners may increase the chance of temporary irritation

If irritation, persistent redness or any unexpected reaction occurs stop using the product and consult a healthcare professional if symptoms do not quickly improve.

Comedogenic Rating

Rating: 0 / 5. Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment is water soluble, contains no heavy oils or waxes and absorbs quickly without leaving a residue that could block pores. It is processed into small molecular fragments that rinse cleanly from skin and does not supply food for acne-causing bacteria, which is why formulators regard it as non-comedogenic.

Suitable for acne-prone or breakout-prone skin.

Keep in mind that the overall pore-clogging potential of a finished product depends on the entire formula, not just one ingredient.

Summary

Hydrolyzed Saccharomyces/Lactobacillus/Ubiquinone Ferment delivers three key perks: antioxidant reducing power from bioavailable Q10, skin conditioning through amino acids and peptides that attract water, and skin protecting support by reinforcing the barrier against daily stressors. All of this comes in a lightweight, water friendly form that mixes easily into serums, lotions and masks.

While not as famous as vitamin C or niacinamide the ferment is gaining steady popularity in K-beauty inspired and clean beauty lines because it offers multi-functional benefits without heaviness.

Overall safety is high with very low rates of irritation or allergy. Still, skin can be unpredictable so it is wise to patch test any new product featuring this ferment before applying it to the entire face.

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