Hydrolyzed Schizosaccharomyces Protein: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Schizosaccharomyces Protein?

Hydrolyzed Schizosaccharomyces Protein comes from Schizosaccharomyces, a type of yeast often used in fermentation. The protein inside the yeast is broken into smaller bits called peptides through acid, enzyme or other forms of hydrolysis. These smaller pieces are water soluble and easy for skin to take in. Interest in yeast-derived ingredients grew when early Japanese sake makers were observed to have smooth youthful hands. Over time cosmetic chemists began to study different yeasts and found that peptides from Schizosaccharomyces could help keep skin feeling soft and healthy. To make the ingredient, suppliers first grow the yeast in controlled tanks, collect the biomass, isolate the protein then hydrolyze it. The finished liquid or powder is filtered and dried so it can slip into many formulas. You will most often see Hydrolyzed Schizosaccharomyces Protein in serums, sheet masks, anti aging creams, daily moisturizers and leave-on treatments that aim to smooth and hydrate the skin.

Hydrolyzed Schizosaccharomyces Protein’s Cosmetic Benefits/Uses

This ingredient is valued for one key role in skincare.

Skin conditioning: The short peptides attract and hold water on the skin surface forming a light film that leaves skin feeling soft and supple. Regular use can improve the look of rough or tired skin making the face appear fresher and well hydrated.

Who Can Use Hydrolyzed Schizosaccharomyces Protein

This gentle yeast-derived peptide works well for most skin types. Dry skin benefits from its water-binding power while normal, combination and oily skin appreciate the light non-greasy feel. Sensitive skin generally tolerates it because it has no harsh acids or strong scents. People with a known yeast allergy should avoid it as a precaution because the source is a yeast species.

The ingredient is made from fermented yeast with no animal parts so it is suitable for vegans and vegetarians.

No data points to risk for women who are pregnant or breastfeeding when the ingredient is used on the skin. Still this is not medical advice and anyone expecting or nursing should review all skincare products with a doctor just to be safe.

Hydrolyzed Schizosaccharomyces Protein does not make skin more sensitive to the sun so there is no extra need for sunscreen beyond normal daily protection.

Potential Side Effects/Adverse Reactions

Side effects from topical Hydrolyzed Schizosaccharomyces Protein can differ between individuals. The points below list potential issues though most users will not notice any problems when the ingredient is properly formulated in a product.

  • Redness or mild irritation in people who are sensitive to yeast extracts
  • Contact dermatitis in rare cases of true allergy to the ingredient
  • Stinging on broken or freshly exfoliated skin

If any discomfort or visible reaction develops stop use right away and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 0/5. Hydrolyzed Schizosaccharomyces Protein is a water-soluble peptide that leaves no oily residue and does not clog pores on its own. Because it sits lightly on the surface and rinses away easily, the risk of blocked follicles is considered minimal.

Suitable for acne-prone or breakout-prone skin.

Keep in mind that the finished product’s overall pore-clogging potential depends on the full formula, not just this single ingredient.

Summary

Hydrolyzed Schizosaccharomyces Protein is mainly used to condition skin by drawing moisture to the surface, forming a light film, and helping the barrier stay smooth and supple. Its small peptides are quickly absorbed and leave a soft hydrated finish.

While not as famous as hyaluronic acid or niacinamide, it has been gaining attention in Korean beauty lines and niche anti-aging serums thanks to its gentle performance and vegan origin.

The ingredient is considered very safe for topical use with only rare reports of irritation in people sensitive to yeast extracts. As with any new skincare product, patch testing is wise before full-face application.

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