Hydrolyzed Sericin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Sericin?

Hydrolyzed Sericin is a water-soluble protein that comes from silk. When silkworms spin their cocoons they produce two main proteins: fibroin, which forms the strong inner fibers, and sericin, which coats those fibers and acts like a natural glue. By breaking sericin down into smaller pieces through a process called hydrolysis, chemists create hydrolyzed sericin, a lightweight form that mixes easily with water-based cosmetics.

The beauty world first took interest in silk proteins in the 1990s when researchers noticed how smooth and hydrated workers’ hands became while handling silk. Over time, manufacturers refined extraction methods so the ingredient could be added to creams, lotions and hair care without losing its natural benefits.

To make hydrolyzed sericin, silk cocoons are cleaned, the sericin layer is separated, then enzymes or gentle acids break the large protein into shorter chains. These shorter chains dissolve in water, giving formulators a versatile liquid or powder that blends well with other ingredients.

You will most often see hydrolyzed sericin in moisturizers, anti-aging serums, sheet masks, leave-in conditioners, shampoos, hair masks and styling creams where extra softness or a silky finish is desired.

Hydrolyzed Sericin’s Cosmetic Benefits/Uses

In skin and hair products hydrolyzed sericin serves two main roles that translate into noticeable beauty benefits.

  • Hair conditioning: The small protein fragments can cling to the cuticle, filling in rough spots and adding a thin protective film. This helps reduce frizz, boost shine and make hair feel smoother without weighing it down.
  • Skin conditioning: On the skin these proteins attract and hold water, improving hydration. They also create a breathable barrier that leaves the surface feeling soft and silky, which can lessen the look of fine lines and dryness.

Who Can Use Hydrolyzed Sericin

This ingredient is generally well tolerated by most skin types, including dry, normal, combination, oily, sensitive and mature skin. Its lightweight, water-soluble nature means it rarely feels heavy or greasy, making it a good fit even for those prone to clogged pores. People with an identified silk or other animal protein allergy should avoid it because it could trigger a reaction.

Hydrolyzed Sericin is sourced from silkworm cocoons, so it is not considered vegan or vegetarian friendly. While some brands market “cruelty-free” silk produced without harming the silkworm, strict vegans may still prefer to skip it and look for plant-based protein alternatives.

Pregnant or breastfeeding women can typically use products containing hydrolyzed sericin because it works only on the surface of skin and hair and is not known to penetrate deeply or enter the bloodstream. This is not medical advice, and anyone who is expecting or nursing should confirm product choices with a healthcare professional.

The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. Normal daily sun protection is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Reactions to topical hydrolyzed sericin differ from person to person. The points below list potential side effects that are possible yet uncommon when the ingredient is used correctly and in appropriate amounts.

  • Allergic contact dermatitis – redness, itching or small bumps in people sensitive to silk proteins
  • Eye irritation – stinging or watering if a product accidentally gets into the eyes
  • Scalp buildup – very heavy or frequent use in hair care may leave a light film that needs clarifying shampoo to remove

If any discomfort, rash or irritation occurs discontinue use and seek medical advice if symptoms persist.

Comedogenic Rating

Rating: 1 / 5

Hydrolyzed Sericin is a water-soluble protein that rinses cleanly from skin and hair. It does not contain heavy oils or waxes that tend to block pores, and its molecular size is small enough to sit lightly on the surface yet large enough to avoid getting trapped inside follicles. Because of this low-residue profile it is unlikely to contribute to blackheads or breakouts.

Suitable for acne-prone skin, though individual responses can vary.

As with most proteins, formula partners matter. If Hydrolyzed Sericin is blended with rich butters or occlusive oils the finished product could be more pore-clogging than the protein itself, so always check the full ingredient list.

Summary

Hydrolyzed Sericin is valued for two main actions: it conditions hair by forming a thin smoothing film on the cuticle, and it conditions skin by drawing in moisture then locking it close to the surface for a soft hydrated feel. These benefits stem from its silk-derived amino acids that are naturally attracted to keratin in hair and skin.

The ingredient enjoys moderate popularity. It shows up in specialty moisturizers, anti-aging serums and premium hair care, but it is less common than plant proteins like soy or wheat due to higher sourcing costs and its non-vegan origin.

Topically applied Hydrolyzed Sericin is considered very safe for most users with only rare reports of allergy or irritation. Still, every formula is different so it is wise to perform a quick patch test when trying a new product that contains this protein.

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