Hydrolyzed Sulfonated Keratin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Sulfonated Keratin?

Hydrolyzed Sulfonated Keratin comes from wool, a natural source of keratin proteins. By treating the wool with acid, enzymes or other gentle hydrolysis methods, the large keratin molecules are broken into smaller fragments that dissolve in water. During the same process the proteins undergo sulfonation, which adds sulfur groups that improve their ability to bind to hair and skin.

Keratin extracts first appeared in salon treatments in the mid-20th century, but early versions were difficult to formulate because the proteins were too large to penetrate or evenly coat hair. Advances in controlled hydrolysis led to smaller, more versatile keratin peptides. Adding sulfonate groups was the next step; it boosted water solubility and created a more flexible ingredient for modern cosmetics.

Production starts with cleaned wool that is minced and suspended in water. Depending on the manufacturer, acid, alkaline or enzymatic hydrolysis is applied under heat to cut the protein chains. The mixture is then neutralized, filtered and subjected to a sulfonation reaction. After purification and drying, the result is a fine powder or liquid concentrate that blends easily into cosmetic bases.

You will most often see Hydrolyzed Sulfonated Keratin in rinse-off and leave-in hair products such as shampoos, conditioners, masks, serums and styling creams. It can also appear in skin care formulas like hand creams, body lotions and masks aimed at boosting softness and hydration.

Hydrolyzed Sulfonated Keratin’s Cosmetic Benefits/Uses

This versatile ingredient offers several helpful roles in beauty formulas

  • Hair Conditioning: The protein fragments form a light-film on strands that helps reduce frizz, smooth the cuticle, add shine and improve manageability without weighing hair down.
  • Humectant: Its sulfonate groups attract and hold water, helping hair and skin stay hydrated for longer periods which reduces dryness and brittleness.
  • Emollient: By filling in microscopic surface gaps, it leaves hair and skin feeling softer and more supple while enhancing a silky finish.

Who Can Use Hydrolyzed Sulfonated Keratin

Because it is lightweight and water soluble, Hydrolyzed Sulfonated Keratin suits most skin and scalp types including dry, normal, combination and oily. Sensitive users usually tolerate it as well since it is a mild protein, but anyone with a known wool or lanolin allergy should proceed cautiously because the ingredient is sourced from wool.

Vegans will want to avoid this ingredient as it is animal derived. Many vegetarians are comfortable with wool sourced materials since the sheep are not harmed, yet that choice depends on personal ethics.

The protein is not known to penetrate deeply or enter the bloodstream so it is generally viewed as safe for people who are pregnant or breastfeeding. This is not medical advice and expectant or nursing mothers should clear any new product with their doctor to be safe.

Hydrolyzed Sulfonated Keratin does not increase photosensitivity so it will not make skin or hair more prone to sunburn.

Potential Side Effects/Adverse Reactions

Reactions to topical Hydrolyzed Sulfonated Keratin vary from person to person. The following lists potential side effects yet most users will not experience them when the ingredient is properly formulated and used as directed.

  • Allergic contact dermatitis in people sensitive to wool proteins or lanolin
  • Mild scalp or skin redness, itching or burning if the formula is highly concentrated
  • Dry or brittle hair when overused in high protein routines
  • Eye irritation if a product accidentally runs into the eyes
  • Product buildup that can weigh down very fine hair when used in leave-ins without proper cleansing

If any irritation or adverse effect occurs stop using the product and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0–1

Hydrolyzed Sulfonated Keratin is a water-soluble protein derived from wool, not an oil or butter, so it does not leave an occlusive film that traps sebum or debris inside pores. Most cosmetic chemists regard hydrolyzed proteins as non-comedogenic or very low risk because they rinse away easily and are used at modest concentrations. For that reason the ingredient earns a 0–1 on the 0–5 scale.

Acne-prone users can generally use products with Hydrolyzed Sulfonated Keratin without worrying about breakouts.

As with any rinse-off or leave-in formula, heavy layering or pairing with rich occlusives could still contribute to buildup over time, so balanced cleansing is wise.

Summary

Hydrolyzed Sulfonated Keratin acts as a hair conditioner, humectant and emollient. Its small protein fragments form a lightweight film that smooths cuticles, enhance shine and add softness. The sulfonate groups attract water, boosting moisture retention in both hair and skin.

While not as famous as plant oils or silicone alternatives, this ingredient has a steady fan base in salon-grade shampoos, masks and some body lotions because it offers visible smoothing benefits without heaviness.

Overall safety is high; reactions are rare and mostly limited to individuals with wool allergies or extreme protein sensitivity. Still, it is smart to patch test any new product to ensure personal compatibility before full use.

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