Hydroxydecyl Ubiquinone Linoleate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydroxydecyl Ubiquinone Linoleate?

Hydroxydecyl Ubiquinone Linoleate is a hybrid molecule created when hydroxydecyl ubiquinone, a fat-soluble form of coenzyme Q10, is chemically joined with linoleic acid, an essential fatty acid commonly found in plant oils such as sunflower and safflower. By linking these two parts, chemists combine the antioxidant power of coenzyme Q10 with the skin-nourishing traits of linoleic acid in a single ingredient.

The idea of pairing coenzyme Q10 with fatty acids started gaining attention in the early 2000s as brands searched for more stable and skin-friendly antioxidants. Traditional coenzyme Q10 is effective but can be tricky to keep active in water-based products. By adding a hydroxydecyl chain then attaching linoleic acid, scientists created a version that blends more easily into creams and lotions while staying potent for longer.

Manufacturing begins with hydroxydecyl ubiquinone produced through fermentation and purification. This compound is then reacted with purified linoleic acid in a controlled setting to form an ester bond that ties the two together. The final material is filtered and tested for purity before it heads to cosmetic labs.

You will most often see Hydroxydecyl Ubiquinone Linoleate in anti-aging serums, moisturizers, eye creams, overnight masks and targeted treatment ampoules where brands want a light yet long-lasting antioxidant boost.

Hydroxydecyl Ubiquinone Linoleate’s Cosmetic Benefits/Uses

This ingredient offers two main functions that work in tandem to support healthier looking skin.

  • Antioxidant: Helps neutralize free radicals generated by UV light and daily pollution which can lead to dullness and fine lines. By cutting down oxidative stress it supports a more even tone and keeps formulas fresher for longer
  • Skin conditioning: The linoleic acid side improves softness and suppleness while reinforcing the skin barrier. This can reduce rough patches and support better moisture retention throughout the day

Who Can Use Hydroxydecyl Ubiquinone Linoleate

This ingredient is generally considered suitable for all skin types. Its lightweight fatty acid side makes it a welcome pick for oily or combination skin while the antioxidant portion supports dry or mature skin that needs extra defense. Sensitive skin usually tolerates it well, though anyone with a known allergy to linoleic acid or coenzyme Q10 should proceed with caution.

Hydroxydecyl Ubiquinone Linoleate is produced through fermentation and plant-based oils so it is appropriate for vegans and vegetarians.

There are no published concerns about topical use during pregnancy or while breastfeeding. That said this information is not medical advice and anyone who is pregnant or nursing should run any skincare product past a doctor just to be on the safe side.

The ingredient itself does not cause photosensitivity. In fact its antioxidant action can help offset some environmental stress caused by sunlight, although daily sunscreen is still important.

Potential Side Effects/Adverse Reactions

Reactions to Hydroxydecyl Ubiquinone Linoleate can differ from person to person. The points below list potential side effects, most of which are uncommon when the ingredient is used correctly in a well-formulated product.

  • Mild redness or stinging on very sensitive skin
  • Temporary itching or dryness if paired with strong exfoliating acids
  • Contact dermatitis in individuals allergic to coenzyme Q10 or linoleic acid
  • Breakouts in users who react poorly to any added fatty acids
  • Yellow staining of fabrics if a high concentration oxidizes on the skin

If you experience any of the above stop using the product and seek guidance from a qualified healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Hydroxydecyl Ubiquinone Linoleate scores a 1 because its linoleic acid side is a lightweight unsaturated fatty acid that tends to reduce pore clogging while the ubiquinone portion is non-oily. Most users, including those prone to blemishes, can use it without seeing an uptick in blocked pores or blackheads.

Keep in mind overall formulation still matters; pairing this ingredient with heavier waxes or butters could raise the chance of congestion.

Summary

Hydroxydecyl Ubiquinone Linoleate works as an antioxidant and skin-conditioning agent. The ubiquinone half mops up free radicals generated by sunlight and pollution while the linoleic acid half softens skin and supports a healthy barrier so moisture stays put.

Although not yet a household name, it is turning up in more mid- to high-end serums and moisturizers because brands value its stability and dual action benefits.

Current safety data shows it is well tolerated for most skin types with only rare reports of irritation or breakouts. As with any new skincare ingredient it is smart to patch test first to make sure your skin is happy before applying it all over.

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