What Is Hydroxyphenyl Glycinamide?
Hydroxyphenyl Glycinamide is a lab-crafted molecule that combines a hydroxyphenyl ring with a glycine-based amide. Although its official chemical name is 2-[(3-Hydroxyphenyl)amino]acetamide, most cosmetic labels shorten it for ease of reading. The ingredient does not come from a plant or animal; it is synthesized in controlled factory settings where chemists join a hydroxyphenyl compound with glycine through a simple amidation reaction. This route allows precise quality control and steady supply.
The compound first drew attention in research aimed at balancing excess oil on skin and scalp. When formulators noticed its ability to curb sebum while leaving hair fibers soft, it graduated from the lab to the beauty shelf. Today you may spot Hydroxyphenyl Glycinamide in mattifying face serums, clay or sheet masks, lightweight moisturizers for oily skin, leave-in scalp tonics and even some balancing shampoos.
Hydroxyphenyl Glycinamide’s Cosmetic Benefits/Uses
This ingredient offers a focused set of benefits that help both skin and hair care products perform better.
- Anti-Sebum: Helps regulate the skin’s natural oil production so complexions look fresher for longer. In scalp formulas it can reduce the greasy feel that builds up between washes.
- Hair Conditioning: Coats hair fibers with a thin, weightless layer that boosts softness and manageability without adding extra oil, making it suitable for fine or oily hair types.
Who Can Use Hydroxyphenyl Glycinamide
Because it helps temper oil without stripping moisture, Hydroxyphenyl Glycinamide is a good match for oily, combination and normal skin. Dry or highly sensitive skin may find it a touch too mattifying if used in a high-strength leave-on formula, though most rinse-off or balanced blends pose little risk. Hair types that get greasy at the roots yet feel limp from heavier conditioners also tend to benefit.
The molecule is fully synthetic and contains no animal-derived components so it aligns with vegan and vegetarian preferences. As always, check the finished product for additional ingredients that may not share the same status.
No published data links Hydroxyphenyl Glycinamide to issues in pregnancy or while breastfeeding. Current evidence suggests it stays near the skin surface instead of entering deeper circulation, but research is limited. This is not medical advice; anyone who is pregnant or nursing should discuss new skincare with a qualified doctor before use.
The ingredient does not absorb UV light or trigger sun-induced reactions, so it is not considered photosensitising. It also plays well with most other common actives such as niacinamide or salicylic acid, making formulation layering straightforward.
Potential Side Effects/Adverse Reactions
Responses to topical Hydroxyphenyl Glycinamide vary from person to person. The effects listed below are possible but unlikely for the average user when the ingredient is blended and preserved correctly.
- Mild transient dryness – some users may feel tightness if their skin is already low on oil
- Localized irritation – redness, itching or warmth can appear on highly reactive skin
- Contact dermatitis – rare allergic reaction marked by rash or swelling
- Flaking on the scalp – excessive oil reduction can occasionally lead to visible flakes
- Stinging if accidently rubbed into eyes – rinse thoroughly with water if this occurs
If any discomfort or visible irritation develops stop using the product and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5
Hydroxyphenyl Glycinamide is water soluble, lightweight and lacks the greasy lipids that tend to clog pores. It regulates oil rather than adding to it, so the chance of it blocking follicles is extremely low.
That makes it generally suitable for people who are prone to acne or frequent breakouts. Keep in mind that the full product formula, especially added oils or waxes, can raise the overall comedogenicity even if this single ingredient scores a zero.
Summary
Hydroxyphenyl Glycinamide mainly delivers two perks: it reins in excess sebum on skin and scalp and it smooths hair fibers for softer, easier styling. It achieves these goals through a small polar structure that can interact with oil glands to temper secretion while forming a light conditioning layer on hair without buildup.
The molecule is still a niche player compared with classics like salicylic acid or panthenol, yet formulators focused on oil control increasingly turn to it because it offers targeted benefits without the heaviness of traditional conditioners.
Current research and user reports suggest it is low risk for irritation, noncomedogenic and vegan friendly. As with any new cosmetic product it is wise to do a quick patch test first to rule out personal sensitivities.