Isohexadecane: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Isohexadecane?

Isohexadecane is a highly refined, branched hydrocarbon made up of 16 carbon atoms. It usually starts as a fraction of mineral oil that is put through a series of purification steps like hydrocracking and hydrogenation to remove impurities and leave a clear odorless liquid.

Cosmetic chemists adopted it in the late 1960s when they were searching for lighter alternatives to heavier oils. Its silky slip and quick-dry feel soon made it popular in everything from long-wear foundations to makeup removers.

You can also spot it in moisturizers, sunscreens, hair styling creams, deodorants and cleansing balms where a weightless yet cushiony texture is wanted.

Isohexadecane’s Cosmetic Benefits/Uses

In formulas Isohexadecane serves two key jobs that give products their smooth glide and easy spread.

  • Emollient: Coats skin or hair with a thin layer that feels light and non-greasy yet helps lock in moisture so the surface stays soft smooth and flexible
  • Solvent: Breaks down and carries pigments oils and sunscreen filters allowing them to mix evenly which boosts stability and makes the finished product go on evenly and rinse off cleanly

Who Can Use Isohexadecane

Thanks to its weightless feel and low tendency to clog pores isohexadecane generally plays well with most skin types. Oily and combination skin appreciate the dry touch finish while dry skin benefits from the soft protective film it leaves behind. Sensitive skin usually tolerates it too because the molecule is chemically inert though a very small number of people might still experience redness or itching if they react to petroleum based ingredients.

Isohexadecane comes from mineral oil not animals so it is suitable for vegans and vegetarians. It is also free of common allergens like gluten soy and dairy.

No studies have flagged isohexadecane as risky for women who are pregnant or breastfeeding. The ingredient sits on the skin surface rather than being absorbed in meaningful amounts so it is considered safe in leave on and rinse off products. This is not medical advice and anyone who is pregnant or nursing should confirm with a doctor before adding new skincare to their routine just to be sure.

Isohexadecane does not increase photosensitivity so there is no added need for sun avoidance beyond normal daily SPF use. It is also odorless and colorless which helps lower the chance of fragrance or dye related irritation.

Potential Side Effects/Adverse Reactions

Skin responses vary from person to person. The side effects below are possible yet uncommon when isohexadecane is used in properly formulated cosmetics so most people will not run into problems.

  • Mild skin irritation such as redness or itching especially in those already sensitive to mineral oil fractions
  • Contact dermatitis in rare cases of true allergy
  • Folliculitis or small breakouts in individuals who are extremely acne prone
  • Temporary eye stinging if a product containing isohexadecane is accidentally rubbed into the eyes before rinsing

If you notice any discomfort stop using the product and seek advice from a doctor or dermatologist.

Comedogenic Rating

Rating: 1 out of 5. Isohexadecane has a large branched structure that sits on the surface and does not easily seep into pores, so it is far less likely to trap dead cells or mix with sebum in a way that sparks breakouts. Most acne prone users tolerate it well, though extremely oily skins that react to any film forming ingredient might still want to monitor how their skin responds. Its low rating also means it is often chosen to thin out thicker oils in formulas without raising the overall clogging potential.

Summary

Isohexadecane acts mainly as an emollient and solvent. It spreads in a thin uniform layer that softens skin or hair while helping lock in water, and its dissolving power keeps pigments, UV filters and other oily actives evenly suspended so products apply smoothly and wear longer. Because it feels dry and non greasy it has become a staple in long wear makeup, lightweight moisturizers, cleansing balms, sunscreens and hair stylers, though it is not as buzzed about as plant based oils so casual shoppers may overlook it on ingredient lists.

Current safety data classifies isohexadecane as low risk for irritation or toxicity, with very rare reports of allergy. As with any new cosmetic it is wise to do a quick patch test on a small area first to make sure your skin agrees with the formula that contains it.

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