Isostearamidopropyl Ethylmorpholinium Ethosulfate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Isostearamidopropyl Ethylmorpholinium Ethosulfate?

Isostearamidopropyl Ethylmorpholinium Ethosulfate is a quaternary ammonium compound crafted for modern hair care. It begins with isostearic acid, a fatty acid usually sourced from vegetable oils like rapeseed or soybean. Chemists convert this fatty acid into an amide, link it to a morpholine ring, then finish the molecule with an ethyl sulfate group. The result is a positively charged ingredient that readily bonds to the negatively charged surface of hair.

Quats became popular in the 1950s as an alternative to animal-derived conditioning agents. Over time formulators looked for versions that felt lighter and rinsed cleaner, which led to specialty molecules like Isostearamidopropyl Ethylmorpholinium Ethosulfate. Its slimmer structure and plant-based fatty chain suit today’s demand for efficient yet gentle conditioners.

The ingredient is produced in controlled reactors where each step—amide formation, morpholine quaternization and sulfation—is purified to cosmetic grade. Manufacturers then dry or dilute the material into easy-to-use liquid concentrates.

You will most often find it in rinse-off and leave-in conditioners, smoothing masks, color-protecting shampoos and anti-frizz styling creams. Some formulators also add it to nourishing scalp treatments where a light conditioning touch is needed.

Isostearamidopropyl Ethylmorpholinium Ethosulfate’s Cosmetic Benefits/Uses

This ingredient delivers targeted hair benefits that improve both feel and appearance.

  • Antistatic: The positive charge neutralizes static electricity that builds up on hair strands. Less static means flyaways are tamed, hair looks sleeker and it is easier to style in dry or low-humidity environments.
  • Hair Conditioning: It forms a thin, breathable layer along the cuticle that smooths rough spots, adds slip for effortless combing and enhances softness without heavy build-up. The result is hair that feels conditioned yet light.

Who Can Use Isostearamidopropyl Ethylmorpholinium Ethosulfate

This conditioning quat is considered gentle enough for most hair and scalp types, including dry, oily, color treated and sensitive. Because it is lightweight and rinses clean it rarely weighs down fine hair, yet still offers slip for thick or coily textures. People with a known sensitivity to quaternary ammonium compounds should proceed cautiously since any quat can provoke irritation in that small group.

The fatty chain in Isostearamidopropyl Ethylmorpholinium Ethosulfate is normally sourced from plant oils so the molecule itself is suitable for vegans and vegetarians. Those who follow a strict cruelty free lifestyle should still confirm that the finished product and its raw materials were not tested on animals.

Pregnant or breastfeeding individuals are unlikely to absorb meaningful amounts of this ingredient through the scalp and it is not known to interfere with hormones. Still this is not medical advice and anyone who is expecting or nursing should have their doctor review all personal care products for peace of mind.

The ingredient does not make skin or hair more prone to sun damage and has no known interaction with UV exposure. It is also compatible with most styling tools and chemical treatments so users can blow-dry, color or relax their hair without worrying about adverse reactions from this specific conditioning agent.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Isostearamidopropyl Ethylmorpholinium Ethosulfate can vary from person to person. The points below cover potential issues that could occur, yet they remain uncommon when the ingredient is used at standard cosmetic levels.

  • Mild scalp irritation: A tingling or itchy sensation may appear in those with very sensitive skin
  • Contact dermatitis: Rare allergic response marked by redness flaking or small bumps
  • Eye irritation: Stinging and watering can occur if the product runs into the eyes during application or rinsing
  • Product build-up: Overuse in leave-in formulas might leave hair feeling heavy or greasy until washed with a clarifying shampoo
  • Reduced performance alongside strong anionic cleansers: Using a high-foaming shampoo immediately after application can strip the conditioner layer leading to dryness rather than damage

If you notice any discomfort or unusual reaction discontinue use and consult a healthcare professional or dermatologist

Comedogenic Rating

Rating: 1 / 5 (very low)

Isostearamidopropyl Ethylmorpholinium Ethosulfate carries a long fatty chain but it is locked inside a large positively charged molecule that tends to stay on the hair surface rather than sink into facial pores. Most formulas using it are rinse-off conditioners or diluted leave-ins, which further lowers the chance of clogging follicles. Because of this it is generally considered suitable for people prone to acne or breakouts, especially when used in hair care products that are kept away from facial skin.

One extra point worth noting is that any residue from hair products can transfer to the skin around the hairline. If you are worried about breakouts, make sure you rinse thoroughly and cleanse your face after washing or styling your hair.

Summary

Isostearamidopropyl Ethylmorpholinium Ethosulfate works as an antistatic agent and lightweight conditioner. Its positive charge latches onto the negatively charged hair cuticle smoothing rough spots, cutting down static flyaways and adding slip for easier combing without heavy build-up.

You will not see it in every bottle on the shelf, but formulators who want a plant-derived quat that feels lighter than classic conditioners reach for it more and more, especially in modern sulfate-free shampoos and leave-in creams aimed at silky movement rather than heavy coating.

Safety profiles show low irritation potential and virtually no systemic absorption when used at cosmetic levels. Still everyone’s skin and scalp are different so it is smart to patch test any new product that features this ingredient before making it part of your regular routine.

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