Lactamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Lactamide?

Lactamide, also known by its chemical name propanamide 2-hydroxy-, is an amide derivative of lactic acid. Lactic acid itself is a naturally occurring alpha hydroxy acid that can be sourced from the fermentation of sugars found in milk beets and corn. By reacting purified lactic acid with ammonia or an amine under controlled conditions chemists convert the acid group to an amide group creating lactamide. This small molecular change keeps the moisturizing character of lactic acid while reducing its acidity making the ingredient milder on skin.

The cosmetic world took interest in lactamide in the late 1990s when formulators were looking for gentler alternatives to traditional alpha hydroxy acids that could still support skin softness. Because it balances water with the skin’s own natural moisturizing factors lactamide quickly found a place in leave-on products where prolonged contact is key. Today it turns up in lightweight facial serums, daily moisturizers, overnight masks, anti-aging creams and after-sun lotions where a calm skin feel is desired.

Lactamide’s Cosmetic Benefits/Uses

Lactamide serves a single purpose in cosmetic formulations: skin conditioning. By attracting and binding water it helps improve skin hydration which in turn supports smooth texture and a soft supple feel. The ingredient’s mildness allows it to deliver these benefits without the stinging sometimes linked to stronger acids making it well suited to everyday products aimed at boosting comfort and resilience.

Who Can Use Lactamide

Lactamide is generally well tolerated by all major skin types including dry, normal, oily, combination and sensitive. Its gentle profile and water-binding ability make it especially helpful for skin that feels tight or dehydrated. Those dealing with active inflammatory conditions like eczema or rosacea can usually use it but should start with lower concentrations since compromised barriers may react more easily to any new ingredient.

Most commercially produced lactamide is synthesized from plant-derived lactic acid so it is typically suitable for vegetarians and vegans. When in doubt check the product label for a statement on animal-free sourcing.

Pregnant or breastfeeding individuals are not known to face specific risks from topical lactamide because it lacks the exfoliating strength and systemic absorption of stronger acids. That said this is not medical advice and anyone expecting or nursing should confirm suitability with a healthcare professional.

Lactamide does not cause photosensitivity and can be used morning or night without increasing vulnerability to sunburn. Standard daytime sun protection is still recommended to guard against routine UV exposure.

Potential Side Effects/Adverse Reactions

Side effects and reactions to topical lactamide vary from person to person. The points below outline potential outcomes that remain unlikely for most users when the ingredient is included at appropriate levels in a well-formulated product.

  • Mild redness or warmth
  • Transient stinging on very compromised or recently exfoliated skin
  • Itching linked to individual sensitivity
  • Contact dermatitis in the rare event of true allergy

If any of these reactions occur discontinue use and consult a qualified medical professional for assessment and guidance.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Lactamide is a small water-soluble molecule that stays in the aqueous phase of a formula rather than forming an oily film on skin. It lacks the heavy lipids and waxy chains that can trap sebum so it has virtually no pore-clogging potential.

This makes it broadly suitable for people who are prone to acne or frequent breakouts.

Because its role is strictly humectant the overall breakout risk of a finished product will depend more on the companion ingredients than on lactamide itself.

Summary

Lactamide’s main job is skin conditioning through humectant action. By attracting and locking in moisture it helps keep the surface smooth soft and comfortable without the sting sometimes tied to stronger acids.

The ingredient enjoys moderate popularity showing up in gentle hydrating serums daily creams and after-sun lotions while bigger names like glycerin and hyaluronic acid continue to dominate shelves.

Safety data show low irritation and allergy rates. Even so it is wise to do a quick patch test whenever you try a new product that contains lactamide just to be certain your skin approves.

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