Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate?

Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is a skin care ingredient born from the union of plant and probiotic science. It starts with Mesembryanthemum crystallinum, a succulent also called the ice plant, known for its ability to thrive in harsh, salty environments while storing water and minerals in its leaves. An extract is taken from this resilient plant, then fermented with the probiotic microorganism Lactobacillus. During fermentation the bacteria break down large plant molecules into smaller, more skin friendly fragments and produce beneficial metabolites. The resulting lysate—a solution containing the broken bacterial cells and their by-products—holds a blend of amino acids, minerals, antioxidants and humectant sugars that can condition and soothe skin.

Fermentation as a cosmetic technique has grown popular over the past decade because it can enhance the bioavailability and mildness of botanical extracts. Brands looking for naturally inspired, gentle yet effective actives began turning to probiotic-based processes, and Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate emerged as part of this trend. It is typically produced in controlled vats where temperature, pH and oxygen are monitored to encourage Lactobacillus to convert plant nutrients into skin beneficial compounds. After fermentation, the mixture is filtered and sterilized to ensure it is safe for topical use.

You will most often find this ingredient in hydrating or soothing serums, daily moisturizers, leave-on masks, anti-aging creams and post-treatment recovery products that aim to calm visible redness and strengthen the skin barrier.

Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate’s Cosmetic Benefits/Uses

This fermented lysate serves one official function in cosmetics.

Skin conditioning: By delivering a cocktail of moisture binding sugars, calming minerals and antioxidant molecules, the lysate helps soften rough patches, smooth texture and support the skin’s natural barrier. Regular use can lead to a more balanced complexion that feels comfortably hydrated and looks healthier.

Who Can Use Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate

This lysate is generally suitable for all skin types, including dry, oily, combination and sensitive skin, thanks to its gentle moisture replenishing and soothing profile. Those with very reactive or allergy-prone skin may still want to monitor how their skin responds, as even mild ingredients can trigger individual sensitivities.

The ingredient contains no animal-derived material and is produced through fermentation of a plant extract by probiotic bacteria, so it is typically considered vegan and vegetarian friendly. Manufacturers sometimes use nutrient media that can vary between suppliers, so strict vegans may wish to confirm sourcing details with the brand.

Current data indicates no known risks for pregnant or breastfeeding women when the lysate is applied topically in cosmetic amounts. Still, this is not medical advice and anyone who is pregnant or nursing should review any skincare product with their healthcare provider before use.

Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate does not increase photosensitivity, so it will not make skin more prone to sunburn. Regular sun protection is still advised as part of any skincare routine.

Potential Side Effects/Adverse Reactions

Side effects from topical use of Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate can vary from person to person. The points below list potential reactions, but most users will not experience them when the ingredient is included at standard cosmetic levels in a well-formulated product.

  • Mild redness or irritation in very sensitive skin
  • Tingling or transient stinging upon application
  • Allergic contact dermatitis in individuals allergic to any component of the ferment
  • Breakouts if the overall product is too rich for acne-prone skin

If you experience persistent discomfort, swelling or any other concerning reaction, stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0/5 – Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is an aqueous ferment with little to no oil or wax content so it does not block pores on its own. Its molecules are mostly small humectant sugars, amino acids and minerals that sit lightly on skin and rinse away easily.

Because of this the ingredient is generally suitable for people who are prone to acne or breakouts.

Keep in mind that the finished product’s overall formula matters. Heavy occlusive oils, butters or silicones added by the brand can raise the final product’s pore-clogging potential even if the lysate itself is non-comedogenic.

Summary

Lactobacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is used mainly for skin conditioning. Through fermentation the ice plant’s nutrients are broken into smaller fragments while Lactobacillus creates additional metabolites. Together they boost water retention with humectant sugars, calm skin with minerals and antioxidants and reinforce the barrier by supporting a balanced surface environment.

The lysate has a modest but growing presence in skincare, riding the wave of interest in probiotic and fermented actives. You will usually spot it in hydrating serums, barrier creams and post-treatment soothers rather than mass-market cleansers or toners.

Current research and user reports show it to be low risk with only rare irritation. As with any new cosmetic it is wise to patch test first to make sure your skin agrees with the formulation.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search