Lactobacillus/Perilla Frutescens Callus Ferment Filtrate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Lactobacillus/Perilla Frutescens Callus Ferment Filtrate?

Lactobacillus/Perilla Frutescens Callus Ferment Filtrate is a plant-derived ingredient created by fermenting the callus cells of the perilla plant (Perilla frutescens) with the probiotic microorganism Lactobacillus. Perilla is an herb related to mint that has long been valued in Asian cuisine and folk beauty rituals for its antioxidant-rich leaves and seeds. Scientists discovered that callus cells, which are undifferentiated plant cells produced in laboratory culture, can be coaxed into generating concentrated levels of skin-beneficial compounds. By fermenting these callus cells with Lactobacillus, the resulting filtrate becomes packed with small-molecule nutrients, amino acids and sugars that the skin can easily absorb.

The process begins with collecting healthy perilla tissue, from which callus cells are cultured under sterile conditions. These cells are then mixed with a Lactobacillus strain in a controlled environment. Over several days the bacteria break down complex plant matter, creating a broth rich in bioavailable actives. After fermentation the mixture is carefully filtered to remove solids and microbial residue, leaving a clear liquid called the ferment filtrate.

Thanks to its lightweight texture and water-soluble profile, Lactobacillus/Perilla Frutescens Callus Ferment Filtrate shows up in a range of leave-on products such as hydrating essences, sheet masks, daily moisturizers, anti-aging serums and soothing after-sun gels. Formulators prize it for adding a silky feel without heaviness while boosting overall moisture retention.

Lactobacillus/Perilla Frutescens Callus Ferment Filtrate’s Cosmetic Benefits/Uses

This ferment filtrate contributes mainly to skin hydration and softness in topical formulas.

  • Emollient: Smooths and softens the skin surface by filling in tiny gaps between cells, leaving the complexion feeling supple and more comfortable
  • Humectant: Attracts and holds water from the environment and deeper skin layers, helping to maintain optimal moisture levels and reduce the appearance of dryness or fine lines

Who Can Use Lactobacillus/Perilla Frutescens Callus Ferment Filtrate

This ferment filtrate is gentle and water based so it suits most skin types. Dry and dehydrated complexions tend to feel the biggest boost thanks to its humectant action while oily and combination skin appreciate the light texture that adds moisture without a greasy after-feel. Sensitive skin usually tolerates it well because the ingredient contains soothing plant metabolites and lacks common irritants. There are no known concerns for darker skin tones or for skin prone to hyperpigmentation.

The material is derived from plant callus cells and a probiotic microorganism so it is acceptable for both vegans and vegetarians. No animal-derived substances are involved in its production process.

Current data do not indicate any risk specific to pregnancy or breastfeeding. The ingredient is not known to penetrate deeply or act hormonally. Still, this is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding new skincare products just to be safe.

Lactobacillus/Perilla Frutescens Callus Ferment Filtrate does not make skin more sensitive to sunlight, so daytime use does not require extra sun precautions beyond the usual recommendation to apply sunscreen.

Because it is water soluble it rinses off easily and layers well under makeup or sunscreen, making it a versatile pick for both morning and evening routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Lactobacillus/Perilla Frutescens Callus Ferment Filtrate can differ from person to person. The points below outline potential, yet uncommon, side effects. When the ingredient is formulated and used correctly most people will not experience any problems.

  • Mild redness or stinging
  • Temporary itching in very sensitive skin
  • Allergic contact dermatitis in individuals allergic to perilla or related plants
  • Rare breakout flare if the overall formula is too rich for acne-prone skin

If discomfort, rash or any other negative reaction appears stop using the product and consult a medical professional.

Comedogenic Rating

Rating: 0 / 5   This filtrate is completely water based with no heavy oils or waxes that could block pores. The molecules created during fermentation are small and readily absorbed or rinsed away so they do not sit on the skin surface long enough to form comedones. All current industry references list both Lactobacillus ferments and Perilla callus extracts as non-comedogenic.

Because it scores a zero, the ingredient is generally safe for people prone to acne or frequent breakouts.

As always the finished product formula matters; if the ferment is blended with thick occlusives the overall product may still clog pores even though the ferment itself does not.

Summary

Lactobacillus/Perilla Frutescens Callus Ferment Filtrate acts mainly as an emollient and humectant. Its fermentation process yields amino acids, sugars and antioxidants that soften skin while drawing water into the upper layers for lasting hydration. These benefits arrive in a light watery base so users feel moisture rather than residue.

The ingredient is not yet a mainstream buzzword like hyaluronic acid but its presence is growing in Korean skincare, hydrating essences and clean beauty lines where plant ferments are valued for their gentle effectiveness.

Overall safety is high. It is non-comedogenic, vegan friendly and rarely triggers irritation. Still, every complexion is unique, so perform a small patch test whenever trying a new product that features this ferment filtrate.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search