What Is Menaquinone-7?
Menaquinone-7, often shortened to MK-7, is a form of vitamin K2 that belongs to the larger naphthoquinone family of compounds. Naturally it occurs in certain fermented foods like natto and some cheeses, where bacteria convert vitamin K1 from plants into vitamin K2 variants including MK-7. In the cosmetic world, MK-7 is valued for its stability and its ability to dissolve in oils, making it easy to blend into skincare formulas.
Interest in MK-7 for topical use grew in the early 2000s when researchers noted its antioxidant behavior and potential to influence skin lipid balance. Manufacturers typically produce cosmetic-grade MK-7 through controlled bacterial fermentation using Bacillus subtilis cultures. The raw material is then purified, standardized to a specific potency, and encapsulated or solubilized in cosmetic-friendly carriers to protect it from light and oxidation.
You will most often find MK-7 in lightweight facial serums, leave-on treatments aimed at balancing oily skin, brightening masks, daily moisturizers with added UV defense claims, and specialty products that promise to support the skin barrier or even out tone.
Menaquinone-7’s Cosmetic Benefits/Uses
Formulators turn to MK-7 because it delivers several distinct skin benefits in one ingredient
- Anti-Sebum: Helps regulate excess oil on the skin surface which can reduce shine and the appearance of enlarged pores
- Astringent: Provides a mild tightening effect that can leave skin feeling firmer and refine skin texture
- Bleaching: Aids in diminishing the look of dark spots and uneven pigmentation for a more uniform complexion
- Skin Protecting: Offers antioxidant activity that helps defend against environmental stressors and supports the skin barrier
- Uv Filter: Adds an extra layer of protection by absorbing a portion of UV radiation, supporting the overall effectiveness of sunscreen formulas
Who Can Use Menaquinone-7
MK-7’s light oil-soluble texture and balancing properties make it a good fit for most skin types including oily, combination, normal and mature skin. Its anti-sebum action is especially helpful for those who struggle with excess oil or visible pores. Dry or very sensitive skin usually tolerates MK-7 well because it does not aggressively strip lipids, but anyone with a history of quinone allergies should proceed carefully.
The ingredient itself is produced through bacterial fermentation using plant-derived substrates, so it is considered suitable for vegans and vegetarians. Always check the finished product label for non-vegan additives such as beeswax or animal-based emulsifiers.
Current research shows no specific topical risks for pregnant or breastfeeding women, yet systemic vitamin K can interact with certain medications. This article is not medical advice, and those who are pregnant or nursing should ask their physician before adding any new skincare product containing MK-7.
Menaquinone-7 does not increase photosensitivity. In fact its mild UV filtering ability can complement daily sun protection, though it never replaces a broad spectrum sunscreen.
Potential Side Effects/Adverse Reactions
Responses to topical MK-7 differ from person to person. The points below describe potential, not guaranteed, reactions. When formulated and used correctly most people experience no problems.
- Mild skin irritation such as redness or stinging, especially on broken or freshly exfoliated skin
- Transient dryness or tightness if applied too frequently on already dehydrated skin
- Allergic contact dermatitis in individuals sensitive to quinone compounds
- Very rare interaction with anticoagulant medication if widespread application leads to unexpected systemic absorption
If any discomfort, persistent redness or other unwanted effect occurs discontinue use and seek medical advice if symptoms do not resolve quickly.
Comedogenic Rating
Rating: 1 out of 5
Menaquinone-7 is oil-soluble yet has a light molecular weight and does not create an occlusive film, so it is unlikely to trap debris inside pores. Most formula studies report no significant rise in comedone formation when MK-7 is used at common skincare levels of 0.1-1%. The tiny possibility of pore clogging comes from the fact that it is still an oil-friendly vitamin, which is why it earns a conservative score of 1 rather than a perfect 0.
Because of this low rating, MK-7 is generally suitable for acne-prone or breakout-prone skin, especially when blended into lightweight serums, gels or emulsions.
Formulators usually pair MK-7 with non-comedogenic carriers like squalane or caprylic/capric triglyceride, keeping the overall product friendly to congested skin. If you see it combined with heavy butters or waxes, the final product’s pore-clogging risk will depend more on those other ingredients than on MK-7 itself.
Summary
Menaquinone-7 offers a multi-tasking mix of anti-sebum control, gentle astringency, pigment brightening, antioxidant skin protection and a mild boost to UV defense. It achieves these perks by modulating sebum gland activity, lightly tightening surface proteins, interfering with melanin transfer, neutralizing free radicals and absorbing a slice of UVB energy.
While vitamin C and niacinamide dominate the spotlight, MK-7 is carving a niche in modern formulations aimed at balanced, clear and even-toned skin. Its popularity is growing in K-beauty style serums and hybrid sunscreen moisturizers, yet it remains a lesser-known ingredient compared to retinol or peptides.
Topically, MK-7 has an excellent safety record with only rare reports of irritation or allergy. It shows no photo-toxicity and no major contraindications, though anyone on prescription anticoagulants should consult a doctor before heavy use. As with any new skincare addition, patch testing is smart to confirm personal tolerance.