Menthyl Ethylamido Oxalate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Menthyl Ethylamido Oxalate?

Menthyl Ethylamido Oxalate is an organic compound created by joining menthol with a small fragment of oxalic acid and an ethylamide group. Menthol comes from mint plants, while oxalic acid occurs naturally in many leafy greens. When chemists link these parts together they get a crystal-clear substance that melts easily into cosmetic bases. First developed in the early 2000s as a gentle cooling agent, it soon found a place in skin care because its mint-derived backbone offers a fresh feel without the sharp tingle pure menthol can cause. The manufacturing process usually starts with natural or synthetic menthol, which is reacted with oxalyl chloride to form a menthyl oxalate. An ethylamine step follows, giving the final ethylamido structure. Careful control of temperature and purity keeps the finished material stable and odor-free.

You will see Menthyl Ethylamido Oxalate in lightweight moisturizers, refreshing face masks, after-sun gels, anti-aging serums and even some eye creams. Its mild cooling effect pairs well with products marketed for tired or sensitive skin, while formulators also use it in body lotions and hand creams meant to soothe after frequent washing or sun exposure.

Menthyl Ethylamido Oxalate’s Cosmetic Benefits/Uses

In topical products Menthyl Ethylamido Oxalate serves one main purpose.

As a skin-conditioning ingredient it helps the surface of the skin feel softer, smoother and more balanced. The silky texture it imparts can make a formula feel lighter and more refreshing, which is especially welcome in warm weather or post-workout products. When combined with humectants or emollients it enhances the overall comfort factor of the formula, leaving skin feeling cool yet hydrated without a heavy residue.

Who Can Use Menthyl Ethylamido Oxalate

This cooling conditioner suits most skin types including oily, combination, normal and even many sensitive complexions because it delivers a gentle fresh feel without the sharp bite of pure menthol. People with a known allergy to menthol or mint botanicals should avoid it since the molecule still shares that backbone and could trigger a reaction.

The ingredient is produced from menthol that is either plant derived or synthesized in a lab, and no animal-origin substances are involved in standard manufacturing so products using it are typically vegan and vegetarian friendly. Those following cruelty-free lifestyles should still check that the finished brand confirms no animal testing.

No human data point to special risks for pregnant or breastfeeding women when the compound is used topically in cosmetic concentrations. That said this is not medical advice and anyone who is expecting or nursing should run any new skincare item past a healthcare professional to be safe.

Menthyl Ethylamido Oxalate is not known to cause photosensitivity and it remains stable under sunlight so extra sun precautions are not required beyond normal daily SPF use.

Potential Side Effects/Adverse Reactions

Responses to topical Menthyl Ethylamido Oxalate differ from person to person. The points below list potential effects but most users will not experience them if the product is well formulated and used as directed.

  • Mild tingling or cooling that feels uncomfortable rather than pleasant
  • Dryness if applied too often or layered with multiple other astringent ingredients
  • Allergic contact dermatitis in individuals sensitive to menthol or mint derivatives
  • Eye irritation and watering if the formula migrates too close to the lash line

If any of these effects occur stop using the product and consult a medical professional for advice.

Comedogenic Rating

Rating: 1 / 5. Menthyl Ethylamido Oxalate is a low-oil, low-waxy molecule that sits lightly on skin and evaporates or absorbs quickly instead of forming a pore-blocking film. Formulas typically include it at modest levels for a cooling feel rather than as a heavy emollient, further reducing clogging risk. That makes it generally suitable for acne-prone or breakout-prone users, though the rest of the formula still matters. Because it is a mint derivative, any flare-ups are more likely to stem from irritation than from comedogenicity.

There is no widespread data linking this ingredient to fungal acne or malassezia overgrowth, so concerns in that area are minimal.

Summary

Menthyl Ethylamido Oxalate conditions skin while adding a subtle fresh sensation. It softens the surface by smoothing rough spots and enhancing spreadability and it delivers a gentle cool touch thanks to its menthol backbone that activates the same temperature-sensing receptors without the sting of pure menthol. Although effective it remains a niche ingredient found mostly in modern K-beauty style gels, after-sun products and select lightweight creams rather than in mainstream global lines.

Overall safety data show low irritation potential except in those sensitive to mint, no known hormone disruption and no issues with UV instability. It performs well within typical cosmetic concentrations making it a safe bet for most users. As with any new skincare product give your skin a cautious introduction by patch testing first so you can catch any rare sensitivities before applying it to larger areas.

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