What Is Mesyloxybenzyl Methoxyethyl Chlorobenzamide?
Mesyloxybenzyl Methoxyethyl Chlorobenzamide is a lab created molecule that belongs to the benzamide family. Chemists combine a chlorine tagged benzamide core with a methoxyethyl side chain and a mesyloxy (methylsulfonyl oxy) group, steps that help the ingredient interact well with both oil and water in a formula. The compound is entirely synthetic, meaning it does not come from plants or animals, which helps formulators keep its quality steady from batch to batch.
The ingredient first drew attention in the early 2000s when researchers looked for gentler ways to dissolve unwanted body hair without the strong odor associated with older depilatories. Its balanced structure allowed it to weaken the protein bonds in hair while being milder on surrounding skin, so cosmetic chemists started adding it to modern hair removal creams. Over time they also noticed that small amounts left on the skin after rinsing helped it feel soft, opening the door for use in multitasking products.
Manufacturing starts with 4-chlorobenzamide. Through controlled reactions, a methoxyethyl group is attached to the nitrogen atom, then the benzyl position is treated with methanesulfonyl chloride to introduce the mesyloxy group. Each step takes place under strict temperature and pH controls to limit impurities, after which the finished powder is purified, dried and milled for easy dispersion in creams and lotions.
You will most often see Mesyloxybenzyl Methoxyethyl Chlorobenzamide in rinse off depilatory creams, quick wash shower hair removers, pre shave gels, body masks that promise smooth skin, as well as some all in one hair removal and conditioning lotions.
Mesyloxybenzyl Methoxyethyl Chlorobenzamide’s Cosmetic Benefits/Uses
This versatile ingredient brings two main perks when added to personal care formulas:
- Depilatory – it breaks down the keratin bonds in hair shafts so strands can be wiped or rinsed away with minimal tugging, giving skin a smooth feel for several days without shaving
- Skin conditioning – after the hair removal action it leaves a light film that helps skin hold moisture and feel softer which can reduce the dryness often linked to traditional depilatories
Who Can Use Mesyloxybenzyl Methoxyethyl Chlorobenzamide
Most skin types—including normal, oily, combination and moderately dry skin—tolerate this ingredient well thanks to its balanced oil and water affinity. Those with very sensitive or eczema-prone skin may feel a mild sting during use because the molecule works by breaking down hair proteins, a process that can also disrupt fragile skin barriers if left on too long.
The compound is fully synthetic and contains no animal derived material, so it is suitable for both vegans and vegetarians provided the finished product is certified cruelty free by the brand.
No specific studies link Mesyloxybenzyl Methoxyethyl Chlorobenzamide to risks during pregnancy or breastfeeding. Still, data are limited so this information is not medical advice. Pregnant or nursing individuals should show the ingredient list to their healthcare provider before use just to be safe.
The molecule does not absorb UV light and is not known to trigger photosensitivity, so it will not make skin more prone to sunburn. It should, however, be kept off broken or freshly shaved skin and away from eyes and mucous membranes because its keratin-weakening action could cause irritation in those areas.
Potential Side Effects/Adverse Reactions
Reactions to topical Mesyloxybenzyl Methoxyethyl Chlorobenzamide differ from person to person. The issues listed below are only potential side effects and are unlikely for the average user when the product is formulated and used correctly.
- Temporary stinging or burning during the processing time
- Redness or mild swelling shortly after rinsing
- Dry or tight feeling skin if the product is left on longer than directed
- Allergic contact dermatitis presenting as itchy rash or small bumps
- Dark or light skin patches in rare cases of prolonged irritation
- Chemical burn with blistering if used on broken or inflamed skin
- Increased irritation when layered with strong exfoliating acids or retinoids
If any of these reactions occur stop using the product immediately rinse the area with cool water and seek medical advice if symptoms persist or worsen.
Comedogenic Rating
Rating: 1 out of 5 (low likelihood of clogging pores)
Mesyloxybenzyl Methoxyethyl Chlorobenzamide is not an oily or waxy molecule and it is usually used in rinse off formulas, so it spends little time on the skin. Its light conditioning film is water soluble and does not build up inside pores, which keeps the risk of comedones low.
This makes the ingredient generally suitable for people who are prone to acne or breakouts.
Because it is almost always combined with other depilatory agents, watch the complete formula if you are highly blemish prone as added oils or butters, not this molecule, could be the real pore cloggers.
Summary
Mesyloxybenzyl Methoxyethyl Chlorobenzamide works as both a depilatory and a mild skin conditioner. It softens the keratin in hair so strands can be wiped away, then leaves a thin hydrating layer that helps skin feel smooth.
It is still a niche ingredient found mainly in modern hair removal creams and quick shower depilatories, so you will not see it in every aisle yet brands that use it often highlight its lower odor and gentler feel compared with classic sulfur based options.
Current research and real world use point to a good safety profile when products are used as directed, with most reactions limited to short lived stinging or redness. As with any new cosmetic, do a small patch test the first time you try a product that lists Mesyloxybenzyl Methoxyethyl Chlorobenzamide to make sure your skin agrees with it.