What Is Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2?
Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2 is a lab-made peptide that joins two well-known skin rejuvenating fragments, Sh-Oligopeptide-75 and Sh-Oligopeptide-2, with an extra methionine amino acid at the front. The finished chain holds 85 amino acids drawn from the same 20 building blocks found in human skin. Scientists first explored this fusion in the early 2000s while looking for stable, easy-to-produce anti-aging ingredients. Instead of harvesting from animal tissue, they insert a custom gene into harmless E. coli, let the bacteria ferment, then purify the peptide so it is clean and consistent. Because it is water-soluble and gentle, brands blend it into serums, firming creams, sheet masks, eye concentrates and other leave-on treatments aimed at dullness or early signs of aging.
Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2’s Cosmetic Benefits/Uses
This peptide offers several benefits that make formulas both effective and appealing.
- Antioxidant: Helps neutralize free radicals created by sunlight and pollution which can otherwise break down collagen and lead to fine lines
- Skin conditioning: Supports a smoother, softer feel by signaling skin to boost its own renewal processes and by binding water to the surface
- Skin protecting: Reinforces the skin barrier so it is less prone to irritation from everyday stressors and helps maintain a healthy moisture balance
Who Can Use Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2
This peptide is generally well suited to dry, normal, combination and oily skin since it is water based, lightweight and non occlusive. Sensitive skin users often tolerate it because it is fragrance free and has a neutral pH, though anyone with a known allergy to peptides or fermentation by-products should proceed with caution.
The ingredient is produced entirely through microbial fermentation without any animal-derived raw materials, so it is suitable for vegetarians and vegans.
Current research shows no specific risks for pregnant or breastfeeding women when the peptide is applied topically in cosmetic concentrations. That said this is not medical advice and anyone who is pregnant or nursing should review any new skincare product with a qualified healthcare provider to be safe.
Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2 does not make skin more sensitive to sunlight and can be used both morning and night without raising the risk of sunburn, though daily sunscreen is still recommended.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2 can vary from person to person. The points below list potential issues that could occur, but they are uncommon when the ingredient is properly formulated and used as directed.
- Mild redness or warmth shortly after application
- Temporary tingling or stinging sensation
- Localized itching in very sensitive skin
- Rare allergic contact dermatitis characterized by persistent rash or swelling
- Breakouts if paired with comedogenic ingredients in a formula
If any of these effects occur stop using the product and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5
Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2 is a pure, water-soluble peptide with no fatty or waxy components that could clog pores, so it earns a solid zero on the comedogenic scale. Its small molecular size allows it to sit lightly on the skin without blocking follicles. This makes it a safe pick for those prone to acne or frequent breakouts. As always the overall formula matters, so watch for rich oils or butters paired with the peptide that could change a product’s pore-clogging potential.
Summary
Methionyl Sh-Oligopeptide-75 Sh-Oligopeptide-2 is an 85-amino-acid fusion peptide that works as an antioxidant, skin conditioner and skin protectant. It neutralizes free radicals before they damage collagen, signals the skin to renew itself for a smoother texture and helps reinforce the outer barrier to hold moisture and fend off irritation. While not yet a household name, it is quietly gaining traction in targeted serums and eye creams thanks to its stability and gentle profile.
Current research and real-world use show the ingredient is low risk with only minor, infrequent reactions reported. Still, everyone’s skin is different so it is smart to patch test any new product containing this peptide before applying it to the entire face.