What Is Methionyl Sh-Polypeptide-10?
Methionyl Sh-Polypeptide-10 is a lab made peptide created through fermentation in a harmless strain of E. coli. Scientists add a methionyl start code to the gene that makes Sh-Polypeptide-10, then let the bacteria produce the full peptide chain. After the cells grow in large stainless-steel tanks the peptide is separated, filtered and carefully purified so it is safe for skin use.
Peptide technology moved into skincare in the late 1990s when brands looked for gentler alternatives to strong actives. Methionyl Sh-Polypeptide-10 joined the lineup as researchers found that short chains of amino acids could signal skin to look smoother and fresher. Its stable structure, vegan origin and small size make it attractive for modern formulas.
You will most often find this ingredient in leave-on products where it has time to work, such as anti-aging serums, lightweight moisturizers, eye creams, sheet masks and concentrated treatment ampoules.
Methionyl Sh-Polypeptide-10’s Cosmetic Benefits/Uses
Methionyl Sh-Polypeptide-10 is classified as a skin-conditioning agent, meaning its main job is to help the skin feel and look better. In a formula it supports a smoother surface, boosts softness and can give the complexion a more rested appearance over time.
Who Can Use Methionyl Sh-Polypeptide-10
Methionyl Sh-Polypeptide-10 is generally suitable for all skin types including dry, normal, combination and oily skin because it is lightweight and non occlusive. Sensitive skin usually tolerates it well since it is free of fragrance, alcohol and common sensitizers. Those with a history of peptide allergies or extremely reactive skin should still proceed with caution, as individual responses differ.
The ingredient is produced through bacterial fermentation with no animal derived starting materials or by-products so it meets vegan and vegetarian standards.
No data suggest that Methionyl Sh-Polypeptide-10 poses a specific risk during pregnancy or breastfeeding when used topically in cosmetic amounts. That said this information is not medical advice and pregnant or nursing individuals should run any skincare product past their doctor to be on the safe side.
This peptide does not make skin more sensitive to sunlight and has no known effect on photosensitivity. It can therefore be used morning or night, though daily sunscreen is still a key part of any routine.
Potential Side Effects/Adverse Reactions
Reactions to topical Methionyl Sh-Polypeptide-10 vary from person to person. The points below outline potential but uncommon side effects assuming the product has been formulated correctly and stored properly.
- Temporary redness or warmth at the application site
- Mild itching or tingling as the product absorbs
- Localized dryness or flaking if the formula contains a high percentage of the peptide without adequate hydrators
- Rare allergic contact dermatitis in individuals sensitive to peptides or other formula components
If any of these effects occur discontinue use and consult a healthcare professional or dermatologist
Comedogenic Rating
Rating: 0 / 5
Methionyl Sh-Polypeptide-10 is a small water-soluble peptide that does not leave an oily film or create residue that can block pores. It is usually included at low percentages and is paired with lightweight bases, which further reduces any clogging risk. For these reasons its comedogenic rating sits at the bottom of the scale.
Because it is considered non-comedogenic, this ingredient is generally a safe pick for people who are prone to acne or frequent breakouts.
The overall pore-friendliness of a finished product still depends on the entire formula, so very rich creams that feature this peptide could feel heavy on oily skin even if the peptide itself is not an issue.
Summary
Methionyl Sh-Polypeptide-10 is a lab made peptide that conditions skin, helping it feel smoother, softer and better hydrated by supporting the skin’s natural repair signals. Its vegan origin, stability and gentle profile have earned it a place in modern serums, eye creams and masks, though it remains a niche rather than blockbuster ingredient.
Current research and real-world use point to a high margin of safety: it is non-comedogenic, suitable for all skin types and shows a very low rate of irritation or allergy. As with any new skincare product, a short patch test on a small area is a smart step before full-face use.