What Is Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2?
Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 is a lab-crafted fusion peptide made through the fermentation of genetically engineered E. coli. Scientists start by stitching together the DNA sequences that code for Sh-Polypeptide-7, Sh-Oligopeptide-1 and Sh-Oligopeptide-2, then add a methionine “starter” so the cell machinery knows where to begin. During fermentation the bacteria produce a single-chain protein containing 315 amino acids, which is later purified, filtered and gently dried into a fine ingredient ready for skincare labs. Interest in multi-action peptides grew in the early 2000s as brands looked for gentler anti-aging tools than retinol or strong acids. By fusing several well-known signal peptides into one chain, formulators hoped to streamline production costs while giving skin multiple supportive messages at once. Today this peptide blend shows up in lightweight serums, rich anti-aging creams, sheet masks, eye gels, after-sun lotions and post-procedure soothing products.
Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2’s Cosmetic Benefits/Uses
In skincare formulas this ingredient is valued for two key roles
- Skin conditioning – helps skin feel softer and look smoother by supporting a healthy moisture balance and encouraging a more even surface
- Emollient – adds a silky slip that makes creams spread easily while filling in tiny surface gaps for a supple, cushioned finish
Who Can Use Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2
This fusion peptide is generally considered friendly for all skin types, including dry, combination, oily and even sensitive complexions, because it is lightweight and non-occlusive while still offering a cushioned feel. People with very reactive or highly compromised skin may wish to start with low-strength formulas since any new peptide can occasionally tingle on contact, but outright incompatibility is rare.
The ingredient is produced through plant-free microbial fermentation so it is suitable for vegans and vegetarians. That said, always scan the full ingredient list of the final product because a brand could combine the peptide with beeswax, collagen or other animal-derived additives.
No published data links this peptide to problems during pregnancy or breastfeeding. Proteins of this size are not known to penetrate beyond the upper skin layers and the body naturally breaks down peptides into harmless amino acids. Still, this is not medical advice and anyone who is pregnant or nursing should clear all skincare choices with a healthcare professional.
Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 does not increase photosensitivity, so it can be worn both morning and night without raising the risk of sunburn. As usual daytime sunscreen is advised for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 differ from one user to the next. The issues below are possible but unlikely for most people when the peptide is properly formulated and used as directed.
- Transient tingling or warmth some users feel a mild sensation during the first few minutes of application, especially on freshly exfoliated skin
- Redness or irritation rare sensitivity can lead to temporary flushing or mild inflammation
- Localized itching an uncommon immune response may cause surface itch that subsides after rinsing
- Contact dermatitis very rarely an allergic reaction presents as rash, swelling or persistent discomfort
- Breakouts if the finished product contains heavy oils acne-prone skin could experience clogged pores, though the peptide itself is non-comedogenic
If you experience any of the above stop use immediately and seek guidance from a medical professional.
Comedogenic Rating
Rating: 0/5
Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 is a large water-soluble protein fragment that sits on the surface of skin and does not mix with oil in the pore. It has no history of clogging pores in lab tests or user reports and it is typically blended into lightweight serums or lotions that rinse off cleanly. For these reasons the peptide earns a solid 0.
This makes it well suited for people who are prone to acne or frequent breakouts.
Keep in mind the finished product can still cause congestion if it contains heavy waxes or oils so always look at the full ingredient list when shopping.
Summary
Methionyl Sh-Polypeptide-7 Sh-Oligopeptide-1 Sh-Oligopeptide-2 is a lab-made fusion peptide that conditions skin and works as an emollient. It helps skin hold moisture, creates a smooth feel and gives creams a silky spread because its chain of 315 amino acids can lightly coat the surface and fill tiny gaps.
While single peptides like copper tripeptide or palmitoyl pentapeptide have household name status, this three-part fusion is still a niche player found mostly in higher-end anti-aging serums, eye gels and post-procedure soothing masks. Its fan base is growing as brands look for gentler options than strong acids or retinoids.
Safety data so far is reassuring. The peptide is non-comedogenic, vegan friendly and unlikely to trigger irritation for most users. Still, every skin is different so it is smart to patch test any new product containing this ingredient before applying it all over the face.