Methoxy Peg-100: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Methoxy Peg-100?

Methoxy Peg-100 is a synthetic ingredient made by linking about one hundred ethylene oxide units to a single methoxy group, creating a water loving chain known as polyethylene glycol. It comes from petrochemical or plant based ethylene sources that are reacted in a controlled setting to reach the desired chain length. First explored in the mid-20th century for medical applications that needed gentle, water soluble carriers, it soon moved into personal care formulas where its smoothing and moisture binding abilities proved useful. Production involves polymerizing ethylene oxide in the presence of a catalyst, then capping one end of the chain with a methoxy group to make the molecule stable and less reactive.

Thanks to its clear, odorless and non sticky nature Methoxy Peg-100 appears in many water rich products. You will most often find it in lightweight face moisturizers, sheet masks, soothing after-sun gels, sprayable lotions, eye creams and wash-off treatments where a fresh feel is desired.

Methoxy Peg-100’s Cosmetic Benefits/Uses

Formulators choose Methoxy Peg-100 for two main reasons that make products more pleasant to use and more effective

  • Humectant: attracts water from the air and from deeper skin layers to the surface so creams and gels stay moist in the jar and help keep skin feeling hydrated and supple after application
  • Solvent: helps dissolve fragrance oils, active extracts and other ingredients into a uniform solution which prevents separation improves texture and allows actives to spread evenly over the skin

Who Can Use Methoxy Peg-100

Methoxy Peg-100 is generally considered friendly for all skin types, including oily, combination, dry and sensitive skin, because it is lightweight, non greasy and has a low likelihood of clogging pores. Very reactive or allergy-prone skin should still examine full ingredient lists, as irritation can stem from other formula components rather than Methoxy Peg-100 itself.

The ingredient is produced from petrochemical or plant-based sources without animal derivatives, so it is suitable for vegans and vegetarians. Brands that follow cruelty-free standards also tend to approve its use, but those who want certification should look for the appropriate logos on the finished product.

No data suggests that Methoxy Peg-100 poses special risks during pregnancy or while breastfeeding. Still, this is not medical advice and anyone who is pregnant or nursing should have a quick chat with a healthcare professional before introducing new skincare products just to be safe.

Methoxy Peg-100 does not make skin more sensitive to sunlight and has no known interaction with UV exposure. It is water soluble, rinses cleanly and can be paired with most common actives without stability issues.

Potential Side Effects/Adverse Reactions

Reactions to topical Methoxy Peg-100 vary from person to person. The points below list potential side effects, though they are uncommon when the ingredient is used correctly in a professionally formulated product.

  • Mild redness or stinging in very sensitive skin
  • Contact dermatitis in individuals already allergic to polyethylene glycols
  • Increased penetration of other ingredients that themselves may be irritating

If any discomfort, rash or swelling occurs discontinue use and seek guidance from a healthcare provider or dermatologist.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Methoxy Peg-100 is highly water soluble and creates an invisible, weightless film that rinses away easily so it does not build up inside pores. Its large molecular size also limits penetration into follicular openings further reducing any chance of blockage. For these reasons cosmetic chemists classify it as non-comedogenic.

Suitable for acne-prone or breakout-prone skin.

Because it can boost the penetration of other ingredients, any pore clogging oils paired with it could still trigger congestion, but Methoxy Peg-100 itself remains a low-risk choice.

Summary

Methoxy Peg-100 works as a humectant and solvent. It tethers water molecules to keep formulas and skin moist then acts like a liquid carrier that dissolves fragrances, extracts and actives so they spread evenly and stay stable.

It is a quiet helper rather than a headline ingredient so you may not see marketing campaigns built around it, yet it shows up in many gels, lotions and masks because it is reliable, versatile and cost-effective.

Current research and decades of use indicate a strong safety profile with very low irritation or comedogenic risk. Still, skin can react unpredictably so perform a small patch test whenever you try a new product that contains Methoxy Peg-100 just to be sure it suits your unique skin.

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