Methoxy Peg-100/Polyepsilon Caprolactone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Methoxy Peg-100/Polyepsilon Caprolactone?

Methoxy PEG-100/Polyepsilon Caprolactone is a man-made block copolymer created by linking two different building blocks: methoxy-capped polyethylene glycol (PEG-100) and poly(ε-caprolactone). PEG brings water-loving properties while the caprolactone segment is more oil-friendly, giving the molecule a unique ability to bridge water and oil phases in a formula. The raw materials originate from petroleum or plant-derived glycols and caprolactone, which are reacted in controlled conditions to form long repeating chains of both blocks. This ingredient first gained attention in the 1990s when chemists looked for gentler alternatives to strong solubilizers used in skin care. Its win-win balance of mildness and performance led to wider cosmetic use during the 2000s. Production involves ring-opening polymerization of ε-caprolactone followed by capping with methoxy PEG, then purification to remove residual monomers.

You will typically find Methoxy PEG-100/Polyepsilon Caprolactone in lightweight facial moisturizers, hydrating serums, sheet masks, gel-cream textures, sprayable lotions and leave-on conditioners. Brands like it because it keeps water-based and oil-based ingredients evenly mixed while drawing moisture to the skin without a heavy feel.

Methoxy Peg-100/Polyepsilon Caprolactone’s Cosmetic Benefits/Uses

This versatile polymer contributes to formulas in two main ways:

  • Humectant: Attracts and binds environmental moisture to the skin surface helping to maintain supple, plump skin throughout the day which can soften fine lines caused by dehydration
  • Solubilizing: Helps dissolve and evenly disperse oil-soluble ingredients such as fragrances and certain actives into water-based products preventing separation and ensuring consistent performance and texture

Who Can Use Methoxy Peg-100/Polyepsilon Caprolactone

Methoxy PEG-100/Polyepsilon Caprolactone is generally well received by all major skin types. Dry and dehydrated skin often benefit most because the polymer pulls extra water into the surface layers, yet the lightweight feel also suits oily or combination skin that dislikes heavy creams. Sensitive skin usually tolerates it since it is considered a mild, nonionic ingredient, though anyone with a known sensitivity to polyethylene glycols should proceed carefully. There are no specific concerns for darker skin tones or acne-prone users because the ingredient is noncomedogenic and does not interfere with melanin pathways.

The compound is synthesized entirely from non-animal building blocks so it is suitable for vegans and vegetarians. No animal-derived solvents or processing aids are typically used during manufacturing but consumers seeking certification should confirm with the finished brand’s documentation.

Current safety data do not flag any hazards for women who are pregnant or breastfeeding when the ingredient is used in normal cosmetic concentrations. Still, this information is not medical advice; expectant or nursing mothers should review any new skincare routine with their physician just to be safe.

Methoxy PEG-100/Polyepsilon Caprolactone does not make skin more sensitive to sunlight and it does not interfere with sunscreens, so there is no special need for extra sun protection beyond everyday SPF habits.

Potential Side Effects/Adverse Reactions

Responses to topical Methoxy PEG-100/Polyepsilon Caprolactone differ from person to person. The issues listed below are only potential outcomes; most users enjoy trouble-free results when the ingredient is included at normal cosmetic levels.

  • Mild redness or stinging on extremely sensitive skin
  • Transient itching if used on broken or freshly exfoliated skin
  • Allergic contact dermatitis in individuals with a preexisting PEG allergy
  • Eye irritation if the product accidentally gets into the eyes

If any of these reactions occur stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0. Methoxy PEG-100/Polyepsilon Caprolactone is a large water-soluble polymer that sits on the surface rather than sinking into pores so it does not clog them. Its humectant action actually keeps skin hydration balanced which helps limit the overproduction of sebum that can lead to breakouts. For these reasons it is considered safe for acne-prone or congestion-prone skin. Most formulators use it at low levels where it simply aids texture and moisture without leaving any occlusive film.

Summary

Methoxy PEG-100/Polyepsilon Caprolactone works in two key ways: it draws water to the skin thanks to its PEG segment and it keeps oil-based ingredients dissolved and stable through the caprolactone block. This makes it a handy humectant and solubilizer in everything from light gels to spray lotions.

While not a household name it is quietly popular with chemists who want a mild multitasker that improves feel and shelf life without raising safety concerns. Current data shows it is low risk for irritation or allergy unless someone already reacts to PEGs so everyday users can feel comfortable seeing it on an ingredient list.

As with any new skincare ingredient a quick patch test on a small area is wise just to be sure your skin agrees with it before applying liberally.

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