What Is Methoxy Peg-100 Propyl Melittin Amide?
Methoxy Peg-100 Propyl Melittin Amide is a lab-crafted version of melittin, the main peptide found in bee venom, that has been joined to a long chain of polyethylene glycol (PEG). This process, often called PEGylation, makes the peptide more stable and easier to blend into water-based formulas. It is made by reacting methoxy PEG-100 propionaldehyde with natural or bio-identical melittin, then turning the peptide’s N-terminal end into an amide, a small change that improves its skin feel and shelf life.
The idea of using melittin in beauty products grew out of the buzz around bee venom masks in the early 2010s. While raw bee venom can be irritating, scientists discovered that attaching PEG to melittin tones down its sting yet keeps its useful surface activity. This gentler complex found its way into Korean skincare first, then moved into global lines aimed at oily and combination skin.
Today Methoxy Peg-100 Propyl Melittin Amide shows up in lightweight moisturizers, mattifying serums, pore-refining toners, sheet masks and targeted T-zone treatments where excess oil control is the main goal.
Methoxy Peg-100 Propyl Melittin Amide’s Cosmetic Benefits/Uses
The ingredient is prized for one clear purpose in skincare formulas.
Anti-Sebum: It helps curb excess oil on the skin’s surface. By interacting with sebum, it lowers shine, keeps pores from looking overly enlarged and supports a fresher appearance throughout the day. Products featuring this peptide often leave skin feeling comfortably matte without the tightness that strong oil-stripping agents can cause.
Who Can Use Methoxy Peg-100 Propyl Melittin Amide
This peptide suits oily, combination and normal skin that battles midday shine. Its gentle mattifying effect can also benefit acne-prone complexions that do not tolerate strong astringents. Those with very dry or easily irritated skin might find it slightly too oil-absorbing which could accentuate tightness or flaking.
Methoxy Peg-100 Propyl Melittin Amide originates from melittin, the main component of bee venom. Even when the peptide is produced in a lab, the raw sequence traces back to animal sourcing so it is generally considered unsuitable for vegans and strict vegetarians.
No specific warnings exist for pregnancy or breastfeeding, but data on topical use during these stages is limited. This information is not medical advice; anyone who is pregnant or nursing should ask a healthcare professional before adding products with this ingredient to a routine.
The molecule does not make skin more sensitive to sunlight, so it is not classed as photosensitising. It also plays well with most common skincare actives such as niacinamide, salicylic acid and retinoids without destabilising them.
Potential Side Effects/Adverse Reactions
Responses to topical Methoxy Peg-100 Propyl Melittin Amide vary between individuals. The issues listed below are possible yet uncommon when a product is correctly formulated and used as directed.
- Mild stinging or warmth a transient sensation that fades within minutes for most users
- Redness or irritation more likely on compromised or very sensitive skin
- Dry patches or flakiness if used too often on already low-sebum skin
- Allergic reaction rare but possible in anyone allergic to bee products or certain peptides
- Contact dermatitis very uncommon but can occur in highly reactive skin types
Discontinue use and consult a healthcare professional if persistent discomfort or an allergic response develops.
Comedogenic Rating
Rating: 0 / 5
Methoxy Peg-100 Propyl Melittin Amide is a water-soluble peptide that does not form a heavy film on the skin. Its PEG backbone keeps it light and easily rinsed away so it is very unlikely to clog pores. The anti-sebum action also discourages the buildup of oil that can trap debris inside follicles.
This makes the ingredient a good match for people who struggle with acne or frequent breakouts.
The only time pore congestion might show up is if the peptide sits in a formula loaded with rich waxes or butters. In that case the overall product, not the peptide itself, could raise the risk of clogged pores.
Summary
Methoxy Peg-100 Propyl Melittin Amide is mainly added to skincare to temper excess oil and leave a soft matte finish. By pairing the bee-venom peptide melittin with a PEG chain the molecule stays stable in water-based gels and can mix with skin oils, helping them spread out less and appear lighter on the face.
While still a niche ingredient it has been gaining notice in K-beauty inspired products that target shiny T-zones and enlarged pores. Wider use is slow but steady as brands look for gentle oil-control options that do not rely on alcohol or clay.
Current data shows it is generally safe for topical use with low rates of irritation or allergy. As with any new skincare ingredient a small patch test is wise to rule out personal sensitivity before using it over larger areas.