What Is Myristoyl Dipeptide-13?
Myristoyl Dipeptide-13 is a small, lab-made molecule that pairs myristic acid, a fatty acid naturally found in coconut oil and nutmeg, with a short chain of two amino acids known as Dipeptide-13. The fatty part helps the peptide slip into the skin’s surface while the peptide part is designed to signal better skin performance. The idea of joining fatty acids to peptides started gaining traction in the early 2000s when formulators looked for ways to boost the stability and penetration of peptides in skin care. Production begins with plant-derived myristic acid, which is purified then chemically linked to the synthesized dipeptide through a controlled reaction. The final material is a waxy, off-white powder that dissolves in oils and some glycols, making it simple to add during the cool-down phase of cosmetic manufacturing. You will spot Myristoyl Dipeptide-13 in anti-aging serums, firming creams, eye treatments, sheet masks and high-end moisturizers where brands want a lightweight yet targeted skin conditioner.
Myristoyl Dipeptide-13’s Cosmetic Benefits/Uses
In skin care formulas Myristoyl Dipeptide-13 acts as a skin conditioning agent, meaning it helps skin feel softer, smoother and better hydrated. By combining a fatty tail with a signaling peptide, the ingredient can sit on the skin’s surface while encouraging a more supple look, making the overall product feel richer and more comforting without adding heaviness.
Who Can Use Myristoyl Dipeptide-13
Because it is lightweight yet still moisturizing, Myristoyl Dipeptide-13 tends to work well for most skin types including dry, normal and combination skin. Oily or acne-prone users usually tolerate it too since the molecule is present at low levels and has a silky rather than greasy finish. Those with very reactive or compromised skin should read ingredient lists closely in case the final formula contains additional actives that might trigger sensitivity rather than the peptide itself.
The ingredient is synthesized in the lab from plant-derived myristic acid and amino acids so it is suitable for vegetarians and vegans. No animal-based raw materials or by-products are used in its standard manufacturing process.
Current safety data show no specific concerns for pregnant or breastfeeding women when Myristoyl Dipeptide-13 is applied topically in cosmetic amounts. That said this is not medical advice and anyone who is pregnant or nursing should review all skincare products with a qualified healthcare provider for personal reassurance.
Myristoyl Dipeptide-13 does not increase photosensitivity so there is no special need to avoid sunlight beyond using your regular daily sunscreen. It is also fragrance-free and colorless which can be helpful for people trying to limit potential irritants.
Potential Side Effects/Adverse Reactions
Side effects from topical Myristoyl Dipeptide-13 can vary from person to person. The points below outline potential reactions yet most users will not encounter these issues when the ingredient is included at typical cosmetic levels.
- Mild redness or stinging
- Temporary itching in very sensitive skin
- Rare allergic contact dermatitis in individuals allergic to fatty acids or peptides
- Breakouts in users extremely prone to clogged pores when paired with heavier oils
If any uncomfortable reaction occurs discontinue use and consult a healthcare professional or dermatologist
Comedogenic Rating
Rating: 1/5
Myristoyl Dipeptide-13 carries a fatty acid tail yet is used at very low levels and has a lightweight, non-greasy finish so it is unlikely to clog pores. The peptide portion offsets the potential oiliness of myristic acid making the overall molecule more skin compatible. This rating means most acne-prone users can use it without extra worry, though the final formula’s other ingredients still matter. Keep in mind that heavy carriers or occlusive waxes paired with the peptide could raise the breakout risk even if the peptide itself is low on the scale.
Summary
Myristoyl Dipeptide-13 is a lab-crafted skin conditioner that blends a fatty acid for glide with a tiny peptide for signaling, helping skin feel softer, smoother and more supple. By sitting on the surface and encouraging better moisture retention it supports a healthier looking barrier and a lightly firmed appearance.
You will mostly see it in higher-end serums, eye creams and sheet masks rather than mass-market lotions, so it is still considered a niche yet growing ingredient among formulators seeking targeted peptide technology.
Current data show it is low risk for irritation or sensitization when used at cosmetic levels. Still, individual formulas differ and skin can react unpredictably, so it is wise to patch test any new product that lists Myristoyl Dipeptide-13 before full-face application.